The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity.

A quantitative structure-activity relationship (QSAR) study was conducted using nineteen previously synthesized, and tested 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines with proven activities against . In order to computationally design and screen potent antimalarial agents, these compounds with known biological activity ranging from 0.697 to 35.