Publications by authors named "Joelle Trepanier"
Article Synopsis
- ERK3/MAPK6 activates MK5, influencing cardiac fibroblast function and hypertrophy in male mice.
- Male MK5 haplo-deficient mice show reduced cardiac hypertrophy and decreased Col1a1 mRNA when faced with increased cardiac afterload.
- The study reveals that reduced ERK3 leads to lower heart mass and impacts fibroblast behavior, highlighting ERK3's crucial role in cardiac fibroblast biology.
J Am Heart Assoc
February 2021
Article Synopsis
- MK2-null mice show normal survival rates and initial cardiac function, but exhibit early signs of diastolic dysfunction and altered heart rate dynamics.
- MK2 deficiency results in increased expression of key metabolic genes and affects mitochondrial sensitivity in the heart.
- The findings suggest that MK2 plays a crucial role in autonomic heart regulation, mitochondrial function, and early cardiac remodeling during pressure overload.
