Publications by authors named "Joelle Thorgrimson"

This report presents a unique case that illustrates the importance of ocular history and photo documentation of ophthalmologic pathology when waivers are granted. A United States Navy pilot applicant was granted a waiver for a corneal scar of unknown etiology. He chose not to pursue Navy pilot training and reenrolled as a United States Marine Corps pilot applicant.

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Objective: To measure the incidence of poststreptococcal glomerulonephritis (PSGN) and resulting complications in northwestern Ontario, including among Indigenous and rural populations.

Design: Cross-sectional study.

Setting: As the only tertiary care hospital in northwestern Ontario, Thunder Bay Regional Health Sciences Centre (TBRHSC) functions as the primary referral centre for most of the region.

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Despite the use of pneumococcal conjugate vaccines for pediatric immunization, North American Indigenous populations continue to experience high burden of pneumococcal infections. Naturally acquired antibodies, which can protect unvaccinated adults against pneumococcal infections, have not previously been studied in Canadian Indigenous people. We analysed concentrations of natural serum IgG, IgM and IgA antibodies specific to 7 serotype-specific capsular polysaccharides (3, 6B, 9V, 14, 19A, 19F and 23F) in 141 healthy individuals (age between 18 and 80 years), including Indigenous adults living in 2 geographical different areas of Ontario, Canada, and non-Indigenous residing in northwestern Ontario.

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Article Synopsis
  • Haemophilus influenzae serotype a (Hia) has become a significant cause of invasive disease, particularly in young children from Canadian First Nations and Inuit populations, with minimal impact on healthy adults.
  • A study measured serum bactericidal activity (SBA) against Hia and the presence of specific antibodies in adults from two First Nations communities, highlighting higher SBA rates in those from regions with reported cases of Hia disease.
  • The findings indicate that First Nations adults possess naturally acquired antibodies against Hia, suggesting potential epigenetic influences, although further research is needed to clarify the origins and specifics of these antibodies.
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Introduction: Incidence rates of invasive serotype b disease have decreased significantly since the introduction of the Hib vaccine; however, the rates in indigenous populations remain disproportionately high, specifically in the paediatric population. Additionally, with the decline of type b invasive infections, there has been a rebound in the incidence of invasive infections caused by other strains of , particularly serotype a.

Case Presentation: We present a paediatric case of septic arthritis caused by type a in a toddler that was fully resolved following antibiotic therapy.

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