Functional impact of sequence variation in the promoter region of TGFB1.

Pathological deregulation of the transforming growth factor, beta 1 (TGFB1) pathway has been implicated in the development of several major diseases, including cancers. Regulatory variation in the TGFB1 gene may lead to altered TGFB1 expression and activity, and thus, modulate an individual's susceptibility to disease. Here, we performed a study of the functional relevance of cis-acting regulatory variation in the proximal promoter region of the TGFB1 gene.

[Arthrosis pain, limits and functional incapacity in the aged].

The impact of arthritic pain, depression, and perceived health on functional limitations and disability in older persons is not clear. This study investigated the role of arthritic pain in functional limitations and disability in older persons. The sample consisted of 1,211 French-speaking persons aged 65 or older.