Evaluation of the Trauma-Associated Severe Hemorrhage score as a predictor of transfusion in traumatized dogs.

Objective: To retrospectively study the use of the human-based Trauma-Associated Severe Hemorrhage (TASH) score to predict transfusion needs and outcome in a population of traumatized dogs.

Measurements And Main Results: The TASH score (comprising sex, hemoglobin concentration, systolic blood pressure, abdominal effusion, heart rate, base excess [BE], and presence of pelvic/femoral fractures) was applied to 24 dogs presenting to a private veterinary hospital following trauma: 12 dogs that required transfusion of blood products and 12 age- and weight-matched controls that did not. Dogs that required transfusions demonstrated a significantly higher TASH score compared with dogs that did not (10.

Microorganism colonization of peripheral venous catheters in a small animal clinical setting.

Objective: To compare the incidence of microorganism colonization of peripheral venous catheters (PVCs) placed in the Emergency Department (ED) to those placed in a routine preoperative setting. The relationship between catheter tip colonization and patient urgency (as assessed by triage priority) was also evaluated.

Design: Prospective, observational study from January 2021 to October 2021.

Retrospective analysis of the use of canine-specific albumin in 125 critically ill dogs.

Objective: To describe the clinical use of canine-specific albumin (CSA) in critically ill dogs, report adverse events, and evaluate measurable clinical effects of CSA administration.

Design: Retrospective case series from 2019 to 2020.

Setting: Large, urban, private-practice referral and emergency center.

Comparing diagnostic findings and cost of whole body computed tomography to traditional diagnostic imaging in polytrauma patients.

Objective: To compare the diagnostic utility of traditional diagnostic tests (ie, radiographs and focused assessment using sonography for trauma [FAST] scans) to whole-body computed tomography (WBCT) for characterizing injuries in polytrauma patients. A secondary objective was to compare costs of traditional diagnostic tests to WBCT.

Design: Prospective, observational study.

Red cell distribution width, illness severity, and all-cause mortality in dogs admitted to the ICU.

Objective: To determine whether red cell distribution width (RDW) can predict illness severity and mortality risk in a heterogenous population of dogs admitted to the ICU.

Design: Prospective observational study.

Setting: Large, urban, private teaching hospital.

The prognostic value of admission point-of-care testing and modified Glasgow Coma Scale score in dogs and cats with traumatic brain injuries (2007-2010): 212 cases.

Objective: To investigate the association between admission point-of-care parameters and survival to discharge in dogs and cats with traumatic brain injury (TBI).

Design: Retrospective study 2007-2010.

Setting: A rural university teaching hospital and an urban private practice teaching hospital.

The influence of a fast-track service on case flow and client satisfaction in a high-volume veterinary emergency department.

Objective: To assess the benefit of a fast-track service in the emergency department of a large, high-volume veterinary hospital.

Design: Prospective, observational, clinical study.

Setting: Emergency department of an urban, tertiary referral veterinary hospital.

Prospective evaluation of plasma lactate parameters for prognosticating dogs with shock.

Objective: To determine whether admission venous plasma lactate concentration, serially calculated lactate variables, or the Acute Patient Physiologic and Laboratory Evaluation (APPLE ) score could discriminate hospital survivors from non-survivors in dogs presenting to the emergency department with clinical signs of shock.

Design: Prospective case series performed over a 24-month period.

Setting: Large urban private teaching hospital.

A Preliminary Investigation into the Association of Chloride Concentration on Morbidity and Mortality in Hospitalized Canine Patients.

Purpose: To evaluate whole blood chloride concentration and hospital-acquired AKI in hospitalized canine patients. Secondary outcome measures included the volume-adjusted chloride load, in-hospital mortality and length of ICU stay.

Patients And Methods: This is a prospective, observational study.

Influence of cross-match on posttransfusion packed cell volume in feline packed red blood cell transfusion.

Objective: To evaluate the influence of major cross-match on transfusion efficacy based on the change in PCV following packed red blood cell (pRBC) administration in cats.

Design: Retrospective study from January 2000 to December 2010.

Setting: University Teaching Hospital.

Influenza A H5N1 hemagglutinin cleavable signal sequence substitutions.

Eleven influenza A H5N1 hemagglutinin N-terminal cleavable signal sequences, coded by single nucleotide substitutions relative to reference A/Viet Nam/1203/2004, were identified by BLASTN search of GenBank and were characterized by molecular modeling. The signal sequences statistically segregated into two classes of states. Members of one class were uncharged and conformationally compact while members of the second class each carried a 2+ electric charge and were conformationally extended.

HIV-1 GP120 V3 conformational and informational entropies.

In an attempt to analyze structure, function and evolution of HIV-1 GP120 V3, interactions among the Hartree-Fock energy, the conformational entropy and the Shannon entropy were determined for the 1NJ0 set of antibody-bound V3 loop conformers. The Hartree-Fock energy of each conformer was determined at the MINI level with GAMESS. The conformational entropy was determined per conformer and per residue from the mass-weighted covariance matrices.

The HF-SCF energy of HIV-1 MNgp120 V3 hairpin loop conformers.

The purpose of this study is to analyze the structure of the V3 loop of the HIV-1 gp120 molecule at the atomic level. The total energy of each member of the antibody-complexed 16-mer V3 conformer data set of Sharon et al. (PDB 1NJ0) was determined by the Hartree-Fock-self-consistent field (HF-SCF) method and with the GROMOS96 force field.

Histamine as a regulator of allergic and asthmatic inflammation.

The immunologic effects of histamine are exerted via the H1 and H2 histamine receptors (H1R and H2R). The effects of histamine include autoinhibition of histamine release from mast cells and basophils, immunosuppression, and the regulation of the activities of cell-mediated immunity (Th1) and humoral immunity (Th2) cells. The asthma phenotype is associated with relative underexpression of Th1 activities and overexpression of Th2 activities.

Molecular modeling of penicilloate anions: an RHF-SCF analysis.

An ab initio restricted Hartree-Fock self-consistent field (RHF-SCF) analysis of penicilloate anions was performed at the TZV level with GAMESS. Geometry optimization was initialized by the semi-empirical AM1 method followed by optimization at the 6-31++G** level. The total energy obtained was -1116.