The Predictive Validity of Intimate Partner Violence Warning Signs.

Intimate partner violence (IPV) is harmful and prevalent, but leaving abusive partners is often challenging due to investments (e.g., children, shared memories).

How Do People Feel About Mates?

Where do positive feelings about a romantic or sexual partner come from? This article offers an overview of-and imposes some structure on-the enormous literature on mate evaluation, from initial attraction to long-term relationship settings. First, we differentiate between research that identifies the factors that predict positive evaluation on average (i.e.

How individuals perceive their partner's relationship behaviors when worrying about finances.

What role do financial worries play in close relationship functioning? In this research, we examine how financial worry - negative thoughts and feelings about finances - is associated with perceived relationship behaviors. Participants recalled how their partner acted during a recent disagreement (Study 1, = 97 couples) or recalled the frequency of positive and negative behaviors enacted by their partner during the previous week (Study 2, = 99 couples). Feeling more worried about finances was associated with recalling less supportive behavior from one's partner at the disagreement (Study 1) and with perceiving more negative behaviors from one's partner in the last week (Study 2).

Inhibitory interactions of the 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug design features.

The World Health Organization (WHO) identifies several bunyaviruses as significant threats to global public health security. Developing effective therapies against these viruses is crucial to combat future outbreaks and mitigate their impact on patient outcomes. Here, we report the synthesis of some isoindol-1-one derivatives and explore their inhibitory properties over an indispensable metal-dependent cap-snatching endonuclease (Cap-ENDO) shared among evolutionary divergent bunyaviruses.

A large normative connectome for exploring the tractographic correlates of focal brain interventions.

Diffusion-weighted MRI (dMRI) is a widely used neuroimaging modality that permits the in vivo exploration of white matter connections in the human brain. Normative structural connectomics - the application of large-scale, group-derived dMRI datasets to out-of-sample cohorts - have increasingly been leveraged to study the network correlates of focal brain interventions, insults, and other regions-of-interest (ROIs). Here, we provide a normative, whole-brain connectome in MNI space that enables researchers to interrogate fiber streamlines that are likely perturbed by given ROIs, even in the absence of subject-specific dMRI data.

How Do Invested Partners Become Invested? A Prospective Investigation of Fledgling Relationship Development.

Investment-the feeling that one has put considerable resources into a relationship-is theorized to play a key role in relationship persistence. Yet, the development of investment is not well-understood. We recruited 256 individuals in new dating relationships and surveyed them each week for up to 25 weeks.

Dosimetric and radiobiological comparison of IMRT, VMAT, and helical tomotherapy planning techniques in hippocampal sparing whole brain radiotherapy with simultaneous integrated boost for multiple brain metastases.

To compare treatment planning and dosimetric outcomes for hippocampal sparing whole brain radiotherapy (WBRT) with the simultaneous integrated boost (SIB) in brain metastasis (BM) patients using tumour control probability (TCP) and normal tissue complication probability (NTCP) formalism between IMRT, VMAT, and HT techniques. In this retrospective study, the treatment data of 20 BM patients who typically received whole brain radiation with SIB treatment were used. Prescription doses of 30 Gy and 36 Gy was delivered in 10 fractions for WBRT and SIB, respectively.

The Life Cycle of Depends on the Presence of a Microbiome in Polyps Prior to Onset of Strobilation.

's intricate life cycle alternates between benthic polyp and pelagic medusa stages. The strobilation process, a critical asexual reproduction mechanism in this jellyfish, is severely compromised in the absence of the natural polyp microbiome, with limited production and release of ephyrae. Yet, the recolonization of sterile polyps with a native polyp microbiome can correct this defect.

Half Empty Half Full? Biased Perceptions of Compassionate Love and Effects of Dyadic Complementarity.

The prevailing theory on relationship judgments for interaction attributes suggests individuals tend to underestimate a romantic partner's expressions of compassionate love and that such underestimation is beneficial for the relationship. Yet, limited research has incorporated dyadic perspectives to assess how biased perceptions are associated with both partners' outcomes. In two daily studies of couples, we used distinct analytical approaches (Truth and Bias Model; Dyadic Response Surface Analysis) to inform perspectives on how biased perceptions are interrelated and predict relationship satisfaction.

No Remorse: Sexual Infidelity Is Not Clearly Linked with Relationship Satisfaction or Well-Being in Ashley Madison Users.

Past research on extradyadic relationship experiences (including infidelity) often suffers from restricted sampling and retrospective accounts, which may have given researchers a distorted image of what it is like for people to have affairs. In this research, we shed light on the experiences people have during their affairs with a sample of registered users on Ashley Madison, a website geared toward facilitating infidelity. Our participants completed questionnaires about their primary (e.

Antecedents and consequences of LGBT individuals' perceptions of straight allyship.

People often self-identify as allies to the lesbian, gay, bisexual, and transgender (LGBT) community. This research examined on what basis LGBT individuals perceive others to be allies and documents the consequences of perceived allyship. Studies 1a ( = 40) and 1b ( = 69) collected open-ended descriptions of allyship provided by LGBT participants.

Expect and you shall perceive: People who expect better in turn perceive better behaviors from their romantic partners.

People who are happy with their romantic relationships report that their partners are particularly effective at meeting their everyday relational needs. However, the literature invites competing predictions about how people arrive at those evaluations. In pilot research, we validated a scale of concrete, specific relationship behaviors that can be performed by a romantic partner day-to-day.

Ipsilateral and axial tremor response to focused ultrasound thalamotomy for essential tremor: clinical outcomes and probabilistic mapping.

Background: MR-guided focused ultrasound (MRgFUS) thalamotomy has been shown to be a safe and effective treatment for essential tremor (ET).

Objective: To investigate the effects of MRgFUS in patients with ET with an emphasis on ipsilateral-hand and axial tremor subscores.

Methods: Tremor scores and adverse effects of 100 patients treated between 2012 and 2018 were assessed at 1 week, 3, 12, and 24 months.

We're Not That Choosy: Emerging Evidence of a Progression Bias in Romantic Relationships.

Dating is widely thought of as a test phase for romantic relationships, during which new romantic partners carefully evaluate each other for long-term fit. However, this cultural narrative assumes that people are well equipped to reject poorly suited partners. In this article, we argue that humans are biased toward pro-relationship decisions-decisions that favor the initiation, advancement, and maintenance of romantic relationships.

Dysgeusia induced and resolved by focused ultrasound thalamotomy: case report.

Dysgeusia, or distorted taste, has recently been acknowledged as a complication of thalamic ablation or thalamic deep brain stimulation as a treatment of tremor. In a unique patient, left-sided MR-guided focused ultrasound thalamotomy improved right-sided essential tremor but also induced severe dysgeusia. Although dysgeusia persisted and caused substantial weight loss, tremor slowly relapsed.

Predicting optimal deep brain stimulation parameters for Parkinson's disease using functional MRI and machine learning.

Commonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces marked clinical benefits when optimized. However, assessing the large number of possible stimulation settings (i.e.

Probabilistic Mapping of Deep Brain Stimulation: Insights from 15 Years of Therapy.

Deep brain stimulation (DBS) depends on precise delivery of electrical current to target tissues. However, the specific brain structures responsible for best outcome are still debated. We applied probabilistic stimulation mapping to a retrospective, multidisorder DBS dataset assembled over 15 years at our institution (n = 482 patients; n = 303; n = 64; n = 39; n = 76) to identify the neuroanatomical substrates of optimal clinical response.

NUT midline carcinoma in a young pregnant female: a case report.

Introduction: The NUT midline carcinoma is a rare tumor mostly reported in the midline of upper aerodigestive tract and mediastinum. Children as well as adolescents are affected without a gender distribution. A standard treatment is not established.

Use of Functional MRI to Assess Effects of Deep Brain Stimulation Frequency Changes on Brain Activation in Parkinson Disease.

Background: Models have been developed for predicting ideal contact and amplitude for subthalamic nucleus (STN) deep brain stimulation (DBS) for Parkinson disease (PD). Pulse-width is generally varied to modulate the size of the energy field produced. Effects of varying frequency in humans have not been systematically evaluated.

Machine learning uncovers the most robust self-report predictors of relationship quality across 43 longitudinal couples studies.

Given the powerful implications of relationship quality for health and well-being, a central mission of relationship science is explaining why some romantic relationships thrive more than others. This large-scale project used machine learning (i.e.

Mapping the network underpinnings of central poststroke pain and analgesic neuromodulation.

Central poststroke pain (CPSP) is a debilitating and often treatment-refractory condition that affects numerous stroke patients. The location of lesions most likely to cause pain and the identity of the functional brain networks that they impinge upon remain incompletely understood. We aimed to (1) elucidate which lesion locations are most frequently accompanied by pain; (2) explore CPSP-associated functional networks; and (3) examine how neuromodulation interacts with these networks.

Use of Functional Magnetic Resonance Imaging to Assess How Motor Phenotypes of Parkinson's Disease Respond to Deep Brain Stimulation.

Background: Deep brain stimulation (DBS) is a well-accepted treatment of Parkinson's disease (PD). Motor phenotypes include tremor-dominant (TD), akinesia-rigidity (AR), and postural instability gait disorder (PIGD). The mechanism of action in how DBS modulates motor symptom relief remains unknown.