Volumetric analysis of the periodontal microstructure under antiresorptive therapy: an experimental study in rabbits.

Objectives: The objective of this study was to volumetrically assess changes in the periodontal microstructure under antiresorptive therapy.

Materials And Methods: Microtomographic scans from a total of 9 Dutch Belted rabbits having been randomly allocated to either the intravenous administration of amino-bisphosphonate (zoledronic acid) (Za) (n = 5) or a negative control group (nZa) (n = 4) were obtained at 10 months following a repeated drug administration. A quantification of the periodontal space thickness (P.