Publications by authors named "Joel Richard Garbow"
Article Synopsis
- Mammalian models, especially mice, are crucial for studying placental development, and MRI could provide important structural and functional insights.
- Diffusion-weighted MRI can improve understanding of how maternal and fetal blood exchange via the placenta but has faced challenges due to the small size and movement of mouse placentas.
- The study used advanced SPEN MRI techniques and albumin contrast agents to differentiate between maternal and fetal blood flows, revealing distinct diffusion behaviors and correlating structural features with microscopy studies.
Little consideration has been given to the possibility that there could be variations in protein expression that alter susceptibility to tumorigenesis without causing other obvious phenotypic effects. Therefore, we sought to determine if haploinsufficiency for the anti-apoptotic protein Bcl-x(L) would affect tumorigenesis. We chose to study Bcl-x(L) because although bcl-x+/- mice were thought to be phenotypically normal, we and others found that haploinsufficiency for Bcl-x(L) lowers fibroblast resistance to apoptosis in tissue culture.
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