Bulk production and evaluation of high specific activity Re for cancer therapy using enriched WO targets in a proton beam.

Introduction: Rhenium-186g (t = 3.72 d) is a β emitting isotope suitable for theranostic applications. Current production methods rely on reactor production by way of the reaction Re(n,γ)Re, which results in low specific activities limiting its use for cancer therapy.

Comparing the 2,2'-Biphenylenedithiophosphinate Binding of Americium with Neodymium and Europium.

Advancing our understanding of the minor actinides (Am, Cm) versus lanthanides is key for developing advanced nuclear-fuel cycles. Herein, we describe the preparation of (NBu4 )Am[S2 P((t) Bu2 C12 H6 )]4 and two isomorphous lanthanide complexes, namely one with a similar ionic radius (i.e.

Evaluation of nitrogen-rich macrocyclic ligands for the chelation of therapeutic bismuth radioisotopes.

Introduction: The use of α-emitting isotopes for radionuclide therapy is a promising treatment strategy for small micro-metastatic disease. The radioisotope (213)Bi is a nuclide that has found substantial use for targeted α-therapy (TAT). The relatively unexplored aqueous chemistry of Bi(3+), however, hinders the development of bifunctional chelating agents that can successfully deliver these Bi radioisotopes to the tumor cells.