Publications by authors named "Joel P S Choo"
Article Synopsis
- Membrane-bound styrene oxide isomerase (SOI) facilitates the conversion of epoxides to carbonyl compounds through a Lewis-acid-based rearrangement but lacked structural insights into its mechanism.
- Using cryo-electron microscopy and various biochemical techniques, researchers shed light on SOI's structure and catalytic process, identifying key residues and interactions that ensure its high selectivity and specificity.
- The discoveries could enhance the use of SOI for different epoxide substrates and enable its application in novel iron-based chemical reactions.
