Utility and limitations of patient-adjusted D-dimer cut-off levels for diagnosis of venous thromboembolism-A systematic review and meta-analysis.

Purpose: To systematically assess test performance of patient-adapted D-dimer cut-offs for the diagnosis of venous thromboembolism (VTE).

Methods: Systematic review and analysis of articles published in PubMed, Embase, ClinicalTrials.gov, and Cochrane Library databases.

Tram, rail, bicycle: An unhappy triad? Rising incidence and resource consumption of tramline-associated bicycling accidents in Bern, Switzerland.

Bicycle traffic and the number of accidents have been increasing in Switzerland in recent years. However, little is known about specific types of bicycling accidents - such as tramline-associated bicycling accidents (TABA) - that are potentially avoidable. This retrospective single center study of emergency department (ED) consultations analyzed TABA in the city of Bern, Switzerland.

Fluid Overload and Mortality in Adult Critical Care Patients-A Systematic Review and Meta-Analysis of Observational Studies.

Objective: Fluid administration in combination with the increase in vasopermeability induced by critical illness often results in significant fluid overload in critically ill patients. Recent research indicates that mortality is increased in patients who have received large volumes of fluids. We have systematically reviewed and synthesized the evidence on fluid overload and mortality in critically ill patients and have performed a meta-analysis of available data from observational studies.

Renal Function-Adjusted D-Dimer Levels in Critically Ill Patients With Suspected Thromboembolism.

Objectives: Diagnosing thromboembolic disease typically includes D-dimer testing and use of clinical scores in patients with low to intermediate pretest probability. However, renal dysfunction is often observed in patients with thromboembolic disease and was previously shown to be associated with increased D-dimer levels. We seek to validate previously suggested estimated glomerular filtration rate-adjusted D-dimer cutoff levels.

Increased S-100 B levels are associated with fractures and soft tissue injury in multiple trauma patients.

Background: S-100 B protein was identified as a biomarker for traumatic brain injury, but studies suggest that extracranial injuries may also lead to increased S-100 B serum levels. In this study, we aim to quantify the impact of injury patterns on S-100 B levels in patients with suspected multiple trauma.

Methods: Patients with suspected multiple trauma treated at a Level 1 Trauma centre in Switzerland were included in this retrospective patient chart review.

[Sequelae of hernia repair: What are the key issues?].

Sequelae of hernia repair: What are the key issues? Since hernia repair is increasingly performed as day case surgery, general practitioners are becoming progressively involved in postoperative care. Early sequelae must be differentiated from late sequelae of hernia repair. Hematomas, seromas and acute pain are frequent early postoperative problems, while at a later stage recurrence and potentially chronifying pain are of importance.