Publications by authors named "Joel Coste"
Introduction: Although the working population carries the greatest burden of long COVID, occupational and non-occupational factors of the condition have not yet been well documented in this population. The aim of this study was to investigate these factors.
Methods: A nationwide random sampling cross-sectional survey was conducted among the adult population in mainland France after the large Omicron waves in the autumn of 2022.
Objective: In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of biologic disease-modifying antirheumatic drugs (bDMARDs). The objective of the Rheumatism Pain Inhibitory Descending Pathways study was to assess pain thresholds and descending pain modulation in patients with active RA or SpA following introduction of a tumor necrosis factor inhibitor (TNFi).
View Article and Find Full Text PDFBackground And Purpose: Chlormadinone acetate (CMA) is a synthetic progestin for which cases of intracranial meningioma have been reported following prolonged exposure.
Method: An observational cohort study was conducted based on the French national health data system. Women aged 10-70 years and who started CMA between 2007 and 2017 were included.
Article Synopsis
- The study compares the prevalence of depressive symptoms between individuals infected with SARS-CoV-2, with a focus on those experiencing long COVID.
- Data was collected from a representative sample of adults through phone interviews, analyzing various factors, including current symptoms and depressive scores measured by PHQ-9.
- Results show that individuals with long COVID are significantly more likely to exhibit depressive symptoms, particularly around feeling uninterested, fatigued, and having difficulty concentrating.
Article Synopsis
- France experienced a decline in self-reported health (SRH) and increased activity limitations (GALI) among adults from 2017 to 2021, with noticeable changes starting in 2019.
- The percentage of individuals reporting very good or good health dropped from 75.2% in 2017 to 68.5% in 2021, while those reporting activity limitations rose from 21.5% to 25.2% over the same period.
- This decline impacted all demographics, particularly younger people and those from higher socioeconomic positions, suggesting widening socio-territorial inequalities despite overall health deterioration affecting all groups.
Article Synopsis
- The study examined how the risk of post-covid symptoms differed between the first wave (March-May 2020) and the second wave (September-November 2020) of the pandemic in France, focusing on data from a national population-based cohort.
- Results showed a higher risk of 14.6% for post-covid symptoms during the first wave compared to 7.0% in the second wave, indicating an increased adjusted risk ratio of 1.36.
- Factors such as baseline physical and mental conditions, the number of acute symptoms, and educational level influenced the risk, with women also showing higher vulnerability during the first wave.
Background: Nomegestrol acetate (NOMAC) is a synthetic potent progestogen. This study aimed to assess the risk of intracranial meningioma associated with the prolonged use of NOMAC.
Methods: Observational cohort study using SNDS data (France).
Article Synopsis
- - The study evaluated the effectiveness of CT venography (CTV) in diagnosing venous thromboembolism (VTE) in women during the postpartum period across 14 hospitals from 2016 to 2020.
- - A total of 123 women were analyzed, revealing that CTV helped identify additional cases of VTE that CT pulmonary angiography (CTPA) missed, increasing the detection rate from 5.7% to 12.2%.
- - While CTV improved VTE detection, it also resulted in higher radiation exposure compared to CTPA alone, which raises considerations for clinical practice when managing postpartum PE.
Background: Although the global chronic morbidity indicator (GCMI) of the Minimum European Health Module (MEHM) was not specifically designed to monitor chronic disease in the population, it is increasingly used for this purpose in Europe and elsewhere. However, its metrological characteristics have seldom been examined, with various sensitivity issues being raised. The present study investigated the metrological performances of the GCMI and analyzed its implications in terms of prevalence and demographic and socioeconomic gradients of chronic conditions in the population.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to estimate the prevalence of long COVID in adults in mainland France, exploring variations based on different definitions and individual characteristics.
- A survey conducted in late 2022 found that out of 10,615 participants, 54.5% reported COVID-19 infection, with long COVID prevalence varying between 1.2% to 13.4% depending on the definition used, and 4.0% overall in the population.
- The findings highlight that long COVID is a significant issue, with varying impacts on daily life, and suggest the need for more standardized definitions to enhance surveillance and research on this condition.
Objectives: To develop a simple, practical methodology to equate or link equivalent domains of the 36-item Short-Form Health Survey (SF-36) and the Patient-Reported Outcomes Measurement Information System 29-item questionnaire (PROMIS-29) using the Rasch framework.
Study Design And Setting: In April 2016, the PROMIS-29 and SF-36 were completed by 1501 individuals selected to be representative of the French population. For each domain common to the two questionnaires, a Partial Credit Model was fitted to the items related to that dimension in the two questionnaires.
Background: Estimating the risks and impacts of COVID-19 for different health groups at the population level is essential for orienting public health measures. Adopting a population-based approach, we conducted a systematic review to explore: (1) the etiological role of multimorbidity and frailty in developing SARS-CoV-2 infection and COVID-19-related short-term outcomes; and (2) the prognostic role of multimorbidity and frailty in developing short- and long-term outcomes. This review presents the state of the evidence in the early years of the pandemic.
View Article and Find Full Text PDFBackground: To assess the associations between anxiety and depressive symptoms and post-COVID-19 condition (PCC) by exploring the direction of these associations and their relevance in the definition of PCC.
Methods: Nationwide survey among French adults, recruited between March and April, 2022, using a quota method to capture a representative sample of the general population with regard to sex, age, socioeconomic status, size of the place of residence, and region. We included all participants who met the World Health Organization (WHO) definition of PCC in addition to a random sample of participants infected with SARS-COV-2 for at least 3 months but without PCC.
Background: Although still incomplete, the epidemiology of epilepsy shows substantial variations in the burden of the condition according to demographic, social and territorial characteristics. This study aimed to estimate the prevalence of treated epilepsy and to investigate its demographic and spatial distribution in 2020 in France, a country where the nationwide epidemiological situation of the condition remains largely unknown.
Methods: We used the French national health data system, which covers nearly the entire population residing in France (over 67 million of inhabitants in metropolitan and overseas departments).
Background: The epidemiological investigation and surveillance of disability requires well-constructed, invariant, and, if possible, exchangeable measures. However, the current or recommended measures have not been thoroughly investigated with respect to these issues. Here we examined the dimensional structure and invariance of four measures across sociodemographic groups: Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), Budapest Initiative Mark 2 (BI-M2) and Washington Group on Disability Statistics Short Set (WG-SS), and Global Activity Limitation Indicator (GALI).
View Article and Find Full Text PDFBackground And Aim: Few questionnaires are available for routine assessment of dyspnea. The study aimed to design a self-administered questionnaire assessing the impact of chronic dyspnea on daily activities, named DYSLIM (Dyspnea-induced Limitation).
Methods: The development followed 4 steps: 1: selection of relevant activities and related questions (focus groups); 2: clinical study: internal and concurrent validity vs.
Purpose Of The Report: Adrenocortical carcinoma (ACC) is an extremely rare endocrine malignancy, which cannot always be diagnosed during conventional radiology and hormonal investigations. 18 F-FDG PET could help predict malignancy, but more data are necessary to support future guidelines.
Methods: A cohort of 63 patients with histologically proven ACC (n = 55) or metastatic ACC with steroid oversecretion (n = 8) was assembled.
Background: The fear of contracting coronavirus disease 2019 (COVID-19) and the preventive measures taken during the health crisis affected both people's lifestyles and the health system. This nationwide study aimed to investigate the impact of the first wave of the COVID-19 pandemic on hospitalizations and mortality related to geriatric syndromes (GS) in older adults in France.
Methods: The French National Health Data System was used to compare hospital admissions (excluding the main diagnosis of COVID-19) and mortality rates (using multiple-cause and initial-cause analyses, and both including or excluding confirmed/probable COVID-19) related to 10 different GS (dementia, other cognitive disorders and symptoms, delirium/disorientation, depression, undernutrition/malnutrition, dehydration, pressure ulcer, incontinence, fall/injury and femoral neck fracture) from January to September 2020 to rates observed in previous years.
Aetiological and prognostic roles of frailty, multimorbidity and socioeconomic characteristics in the development of SARS-CoV-2 health outcomes: protocol for systematic reviews of population-based studies.
BMJ Open
November 2022
Introduction: There is growing evidence that the impact of COVID-19 crisis may be stronger for individuals with multimorbidity, frailty and lower socioeconomic status. Existing reviews focus on few, mainly short-term effects of COVID-19 illness and patients with single chronic disease. Information is also largely missing for population representative samples.
View Article and Find Full Text PDFBackground: Although sepsis is a life-threatening condition, its heterogeneous presentation likely explains the negative results of most trials on adjunctive therapy. This study in patients with sepsis aimed to identify subgroups with similar immune profiles and their clinical and outcome correlates.
Methods: A secondary analysis used data of a prospective multicenter cohort that included patients with early assessment of sepsis.
Objectives: Multidisciplinary approaches to treating chronic pain have been proven effective. Currently, chronic pain patients face lengthy waitlists in pain medicine departments. To overcome this problem, we developed the "FastSchool" program to educate patients about pain management and treatment.
View Article and Find Full Text PDFPersistent pain despite satisfactory disease treatment is frequent in rheumatoid arthritis (RA) and spondyloarthritis (Spa) and may result from specific changes in central pain processing. We assessed these mechanisms further by systematically comparing thermal pain thresholds and conditioned pain modulation (CPM) between patients with active RA or Spa and healthy controls. We included 50 patients with RA and 50 patients with Spa and 100 age-matched and sex-matched controls.
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