Structure activity relationship, acute toxicity and cytotoxicity of antimycobacterial neolignan analogues.

Objectives: The study's aims were to evaluate the antimycobacterial activity of 13 synthetic neolignan analogues and to perform structure activity relationship analysis (SAR). The cytotoxicity of the compound 2-phenoxy-1-phenylethanone (LS-2, 1) in mammalian cells, such as the acute toxicity in mice, was also evaluated.

Methods: The extra and intracellular antimycobacterial activity was evaluated on Mycobacterium tuberculosis H37Rv.