Combination of olfactory course anterior cerebral artery and accessory middle cerebral artery (MCA) with occluded in situ MCA and related moyamoya phenomenon.

We describe a rare case of congenital persistence of a primitive olfactory anterior cerebral artery in association with an ipsilateral accessory middle cerebral artery. The normally and anatomically positioned, or in situ, middle cerebral artery was occluded. This, along with a well-developed anastomotic network of lenticulostriate artery domains and leptomeningeal collaterals suggested a moyamoya phenomenon.

The vascular supply of the functional compartments of the human striatum.

The basal ganglia (BG) contain several functional compartments and multiple, parallel segregated circuits processing different cortical information through cortical-BG-thalamus-cortical loops. Three zones of corticostriatal input are present: sensorimotor, associative and limbic, which correspond to poor, intermediate and strong calbindin (CB) labelling, respectively. Other functional compartments, such as striosomes, extrastriosomal matrix and matrisomes, also convey segregated projections.

Binding of protein phosphatase 2A to the L-type calcium channel Cav1.2 next to Ser1928, its main PKA site, is critical for Ser1928 dephosphorylation.

The cAMP-dependent protein kinase (PKA) controls a large number of cellular functions. One critical PKA substrate in the brain and heart is the L-type Ca(2+) channel Ca(v)1.2, the activity of which is upregulated by PKA.

Tertiary microvascular territories define lacunar infarcts in the basal ganglia.

Lacunar infarcts are commonly found in the basal ganglia, though little is known about the organization of small-scale microvascular territories that presumably subtend lacunae. We investigated microvascular territories of the lenticulostriate arteries, the recurrent artery of Heubner, the anterior choroidal artery, and striate branches of the anterior cerebral and anterior communicating arteries in perfusion-fixed human brains by simultaneous injection of fluorescent dyes and a radio-opaque substance in 5% gelatin. Territories were defined by ultraviolet illumination of dye and high-resolution mammography of radio-opaque substance.