Multi-Scale Characterisation and Mechanical Adhesion in PVD-Deposited Ca-SZ Coating for Implantable Medical Devices.

Oral implantology faces a multitude of technical challenges in light of current clinical experience, underlining the need for innovation in implantable medical devices in both mechanical and biological terms. This study explores the influence of the thickness factor of calcium-doped zirconia (Ca-SZ) coatings deposited by PVD on their intrinsic mechanical properties and the determinism of the latter on adhesion to the TA6V alloy substrate after mechanical loading for applications in dental implantology. Three separate thicknesses of 250 nm, 450 nm and 850 nm were evaluated in terms of mechanical strength, modulus of elasticity and adhesion to the substrate, in accordance with ISO 20502:2005.

Revealing the composition and optical properties of marine carbonaceous aerosols: A case of the eastern China marginal seas.

Marine aerosols are major components of atmospheric aerosols, playing substantial roles in influencing the regional and global environment and climate. Marine aerosols are not only produced by seawater directly, but also by indirect processes such as atmospheric oxidation of marine bioactive gases as well as terrestrial transport. Over the Eastern China Marginal Seas (ECMS), marine aerosols are strongly affected by marine emission and transport of terrestrial aerosols.

Molecular characteristics of sea spray aerosols during aging with the participation of marine volatile organic compounds.

Sea spray aerosols (SSAs) are one of the largest natural sources of aerosols globally, known to affect the earth's radiation budget and to play a pivotal role in air quality and climate. The physical and chemical properties of organic components in SSA change during long-distance atmospheric transport over the ocean. To characterize the evolution of organic components during the aging process of SSA, in this study, we use a flow reactor to simulate the oxidation processes of SSA produced by authentic seawater via OH radicals (in the presence of organic gases evaporated from seawater) and to present the molecular signatures of the nascent and aged SSA.

Innovative Bioactive Ca-SZ Coating on Titanium Dental Implants: A Multidimensional Structural and Elemental Analysis.

The design of new, biomimetic biomaterials is of great strategic interest and is converging for many applications, including in implantology. This study explores a novel approach to improving dental implants. Although endosseous TA6V alloy dental implants are widely used in oral implantology, this material presents significant challenges, notably the prevalence of peri-implantitis.

True Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: Diagnostic and Therapeutic Considerations-Brief Report.

Donor cell leukemia (DCL) is a rare complication after allogeneic hematopoietic stem cell transplantation (HSCT) accounting for 0.1% of relapses and presenting as secondary leukemia of donor origin. Distinct in phenotype and cytogenetics from the original leukemia, DCL's clinical challenge lies in its late onset.

Mutational patterns in therapy-related acute lymphoblastic leukemia subgroups: one step closer to unveiling the genetic odyssey.

There is increasing evidence that therapy-related acute lymphoblastic leukemia (trALL) resulting from chemo- and/or radiotherapy represents a distinct entity. However, apart from rearrangements, which have been repeatedly reported in this subgroup, the relevance of other aberrations remains controversial due to divergent study results and sparse molecular analyses. Within our ALL patient cohort, 15% ( = 19/131) met the criteria for trALL with a high proportion of Ph + and rearrangements.

Enhanced saccharide enrichment in sea spray aerosols by coupling surface-active fatty acids.

The chemical composition of aerosols plays a significant role in aerosol-cloud interactions and, although saccharides make up their largest organic mass fraction, the current process model for understanding sea spray aerosol (SSA) composition struggles to replicate the enrichment of saccharides that has been observed. Here, we simulated the generation of SSA and quantified the enrichment of two soluble saccharides (glucose and trehalose) in SSA with a homemade sea spray aerosol generator. The results of the generation experiments demonstrated that both saccharides, especially trehalose, can promote the generation of SSA, whereas surface-active fatty acids primarily inhibit SSA production due to fewer bubble bursts caused by a large amount of foam accumulation.

Zirconia Dental Implants: A Closer Look at Surface Condition and Intrinsic Composition by SEM-EDX.

Modern dental implantology is based on a set of more or less related first-order parameters, such as the implant surface and the intrinsic composition of the material. For decades, implant manufacturers have focused on the research and development of the ideal material combined with an optimal surface finish to ensure the success and durability of their product. However, brands do not always communicate transparently about the nature of the products they market.

Edible Coating Formulated by Optimization from , Starch, and Arabic Gum Improved the Conservation of Banana () Fruits.

Banana is a very perishable climacteric fruit with consequence of large postharvest losses. The objective of the present study was to improve the postharvest shelf life of bananas. Fruits from the Melong locality were treated with coating solutions formulated with a mixture of , starch, and Arabic gum at different concentrations.

An overview of natural products that modulate the expression of non-coding RNAs involved in oxidative stress and inflammation-associated disorders.

Oxidative stress is a state in which oxidants are produced in excess in the body's tissues and cells, resulting in a biological imbalance amid the generation of reactive oxygen and nitrogen species (RONS) from redox reactions. In case of insufficient antioxidants to balance, the immune system triggers signaling cascades to mount inflammatory responses. Oxidative stress can have deleterious effects on major macromolecules such as lipids, proteins, and nucleic acids, hence, Oxidative stress and inflammation are among the multiple factors contributing to the etiology of several disorders such as diabetes, cancers, and cardiovascular diseases.

Ex vivo drug response heterogeneity reveals personalized therapeutic strategies for patients with multiple myeloma.

Multiple myeloma (MM) is a plasma cell malignancy defined by complex genetics and extensive patient heterogeneity. Despite a growing arsenal of approved therapies, MM remains incurable and in need of guidelines to identify effective personalized treatments. Here, we survey the ex vivo drug and immunotherapy sensitivities across 101 bone marrow samples from 70 patients with MM using multiplexed immunofluorescence, automated microscopy and deep-learning-based single-cell phenotyping.

Off grid PV/Diesel/Wind/Batteries energy system options for the electrification of isolated regions of Chad.

Access to reliable energy is fundamental for the development of any community. The electricity is produced in Chad solely from thermal plants that use fossil fuels, which are not environmentally friendly. In addition, the electrification rate of Chad is less than 11%.

Disruption of Biofilm Formation and Quorum Sensing in Pathogenic Bacteria by Compounds from Zanthoxylum Gilletti (De Wild) P.G. Waterman.

Microbial resistance is facilitated by biofilm formation and quorum-sensing mediated processes. In this work, the stem bark (ZM) and fruit extracts (ZMFT) of Zanthoxylum gilletii were subjected to column chromatography and afforded lupeol (1), 2,3-epoxy-6,7-methylenedioxyconiferyl alcohol (3), nitidine chloride (4), nitidine (7), sucrose (6) and sitosterol-β-D-glucopyranoside (2). The compounds were characterized using MS and NMR spectral data.

Bioactive Clerodane Diterpenoids from the Leaves of Vent.

Vent., an endemic plant from the Mascarene Islands, was investigated following its antiplasmodial potentialities highlighted during a previous screening. Three clerodane diterpene compounds were isolated and identified as being responsible for the antiplasmodial activity of the leaves of the plant: caseamembrin T (), corybulosin I (), and isocaseamembrin E (), which exhibited half maximal inhibitory concentrations (IC) of 0.

Chemical reaction, Dufour and Soret effects on the stability of magnetohydrodynamic blood flow conveying magnetic nanoparticle in presence of thermal radiation: A biomedical application.

Nowadays ferrofluids (magnetic nanofluids) are at the center of many researches because of their major biomedical applications such as drug delivery and cancer treatment. The effects of chemical reaction, temperature gradient induced mass transfer and concentration gradient induced heat transfer on the stability of ferrofluid flow are of great importance. This paper deals with a stability analysis of a ferrofluid composed of blood as base fluid and magnetic nanoparticles.

High genotypic diversity of human papillomavirus among women in Cameroon: implications for vaccine effectiveness.

Background: The burden of human papillomavirus (HPV) is high in Cameroon, but knowledge on high-risk oncogenic HPV (HR-HPV) is limited. Our study sought to ascertain the HR-HPV genotypes circulating in Cameroon.

Methods: A cross-sectional study was conducted among non-vaccinated women in Cameroon.

Echinograciolide, a new antibacterial nor-triterpenoid and other constituents from O. Hoffm. (Asteraceae).

Antibacterial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antibacterial activity of extracts and compounds from O. Hoffm.

Near-tetraploid T-cell acute lymphoblastic leukaemia in childhood: Results of the AIEOP-BFM ALL studies.

Background: Near-tetraploidy-defined by DNA index 1.79-2.28 or 81-103 chromosomes-is a rare cytogenetic abnormality observed both in children and adults with T-cell acute lymphoblastic leukaemia (T-ALL) and its prognostic value is not yet determined.

Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells.

A hallmark of primate postimplantation embryogenesis is the specification of extraembryonic mesoderm (EXM) before gastrulation, in contrast to rodents where this tissue is formed only after gastrulation. Here, we discover that naive human pluripotent stem cells (hPSCs) are competent to differentiate into EXM cells (EXMCs). EXMCs are specified by inhibition of Nodal signaling and GSK3B, are maintained by mTOR and BMP4 signaling activity, and their transcriptome and epigenome closely resemble that of human and monkey embryo EXM.

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility.

Titanium dental implants have common clinical applications due to their biocompatibility, biophysical and biochemical characteristics. Although current titanium is thought to be safe and beneficial for patients, there are several indications that it may release toxic metal ions or metal nanoparticles from its alloys into the surrounding environment, which could lead to clinically relevant complications including toxic reactions as well as immune dysfunctions. Hence, an adequate selection and testing of medical biomaterial with outstanding properties are warranted.

Biocompatibility of ZrO vs. Y-TZP Alloys: Influence of Their Composition and Surface Topography.

The osseointegration of implants is defined as the direct anatomical and functional connection between neoformed living bone and the surface of a supporting implant. The biological compatibility of implants depends on various parameters, such as the nature of the material, chemical composition, surface topography, chemistry and loading, surface treatment, and physical and mechanical properties. In this context, the objective of this study is to evaluate the biocompatibility of rough (Ra = 1 µm) and smooth (Ra = 0 µm) surface conditions of yttria-zirconia (Y-TZP) discs compared to pure zirconia (ZrO) discs by combining a classical toxicological test, morphological observations by SEM, and a transcriptomic analysis on an in vitro model of human Saos-2 bone cells.