A novel smartphone application for bladder cancer management (BCM App): Design, development, and usability evaluation.

Background: Providing clinical guidelines to clinicians using innovative technologies seems practical and useful. This study aimed to design, develop, and evaluate a smartphone application to assist urologists in managing bladder cancer (BCM App).

Materials And Methods: The study was conducted in three phases, following the user-centered design model, at the urology clinic of Khorshid Hospital (Isfahan, Iran) in 2021.

Immunological characterization of recombinant outer membrane Loa22 protein of local pathogenic serovars.

Leptospirosis is a worldwide zoonotic disease caused by pathogenic spp, often occurring in tropical and subtropical regions. Focusing on development of rapid diagnostic methods to facilitate early diagnosis and a universal vaccine are the main critical issues to overcome the burden of leptospirosis. Here, we have studied the immunogenic potential of prepared recombinant Loa22 protein (rLoa22) of local pathogenic species in mice and its ability to induce humoral and cellular immunity, being further evaluated by analyzing the immunoglobulin G (IgG) subclasses and cytokines produced through immunization.

Application of pulsed-field gel electrophoresis for molecular identification of pathogenic species in Iran: a rapid and reliable method.

Background And Objectives: Leptospirosis is a zoonotic disease caused by pathogenic serovars. The genus cannot differentiated by conventional techniques. However, identity determination of pathogenic serovar is precious of public health problems and epidemiological studies.

Nurses' perceptions of patient safety competency: A cross-sectional study of relationships with occurrence and reporting of adverse events.

Although, strengthening patient safety competencies in nursing has been emphasized for enhancing quality care and patient safety. However, little is known about the association of nurses' perceptions of patient safety competency with adverse nurse outcomes in Iranian hospitals. This study aimed to measure nurses' levels of patient safety competency in the hospitals of Iran and examines the relationship between patient safety competency with the occurrence and reporting of adverse events (AEs).

Improvement the expression and purification of Loa22: a lipoprotein with OmpA domain from pathogenic serovars.

Background And Objectives: One of the highly conserved outer membrane proteins expressed only by pathogenic Leptospires is Loa22. The study aims is to achieve the optimum conditions for high expression of recombinant Loa22 (rLoa22) protein.

Materials And Methods: Complete coding sequence of gene sub-cloned into a pET32a (+) expression vector.

Application of a Multiplex PCR Assay for Molecular Identification of Pathogenic and Non-Pathogenic Leptospires based on lipL32 and Genes.

Leptospirosis is a serious zoonotic infection and the most prevalence disease is in the tropical and subtropical region. The definitive diagnosis of Leptospirosis, caused by spirochetes of the genus infection is already using culture methods, serological tests such as the microscopic agglutination test (MAT) and molecular detection methods (PCR) are possible. In this study, we used multiplex PCR method for detection of pathogenic and non - pathogenic based on and genes.

Ni(ii) immobilized on poly(guanidine-triazine-sulfonamide) (PGTSA/Ni): a mesoporous nanocatalyst for synthesis of imines.

Mesoporous materials have been the subject of intense research regarding their unique structural and textural properties and successful applications in various fields. This study reports a novel approach for synthesizing a novel porous polymer stabilizer through condensation polymerization in which FeO magnetic nanoparticles (FeO MNPs) are used as hard templates. Using this method allowed the facile and fast removal of the template and mesopores formation following the FeO MNPs.

A sensitive determination of morphine in plasma using AuNPs@UiO-66/PVA hydrogel as an advanced optical scaffold.

In this study, a novel turn-on fluorescence nanoprobe structure has been developed by in situ synthesis and embedding of gold nanoparticles (AuNPs) and Zr-based metal-organic frameworks (MOFs), UiO-66, in polyvinyl alcohol (PVA) hydrogel for sensitive quantification of morphine in human plasma samples. A three-dimensional network of PVA hydrogel was formed by simultaneously penetrating UiO-66 and gold ions in the hydrogel frame and reducing to AuNPs without adding any reducing agent. The morphology and characterization of this new PVA-based nanocomposite hydrogel were studied by transmission electron microscopy, dynamic light scattering instrument, energy-dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy.

Diagnostic value of intravenous oxygen saturation compared with arterial and venous base excess to predict hemorrhagic shock in multiple trauma patients.

Introduction: In this study, with the help of peripheral vein sampling, Spvo2, and peripheral artery and vein sampling, we examined base excess (BE) in trauma patients and determined its diagnostic value for hemorrhagic shock.

Methods: In this cross-sectional study, from 64 patients with abdominal, pelvic and chest Blunt trauma who have a score of 2 or higher trauma during treatment, blood samples were taken from peripheral vein to measure oxygen saturation and peripheral vein and artery for BE measurements and were compared in order to assess their diagnostic value in predicting the occurrence of hemorrhagic shock.

Results: Out of 60 examined patients, 43 (71.

Effect of vitamin D supplementation versus placebo on essential hypertension in patients with vitamin D deficiency: a double-blind randomized clinical trial.

Findings from randomized trials addressing the effect of vitamin D supplementation and blood pressure are inconsistent and have been the subject of recent debate. This study aimed to assess the effect of vitamin D supplementation on primary hypertension. This double-blind randomized clinical trial was conducted on patients aged 26-84 years with essential hypertension from March 2017 to April 2019.

Multifunctional Ground Control Points with a Wireless Network for Communication with a UAV.

Ground control points (GCPs) are commonly used for georeferencing in remote sensing. Precise position measurement of the GCPs typically requires careful ground surveying, which is time-consuming and labor-intensive and thus excessively costly if it needs to be repeated multiple times in a season. A system of multifunctional GCPs and a wireless network for communication with an unmanned aerial vehicle (UAV) was developed to improve the speed of GCP setup and provide GCP data collection in real-time during the flight.

Evaluation of highly sensitive immunoassay technologies for quantitative measurements of sub-pg/mL levels of cytokines in human serum.

A comprehensive cross-platform and cross-assay evaluation using nine technology platforms and four cytokine immunoassays (IL-6, TNFα, IL-17a, IL-2) was performed by comparing assay precision, sensitivity, parallelism and data correlation between platforms. The precision was acceptable for most evaluated assays. In addition to comparing the analytical assay sensitivity using a spiked recombinant analyte in buffer, forty serum samples from both normal controls and multiple sclerosis patients were used to measure the frequency of endogenous analyte detection (FEAD) as a parameter of each assay's ability to detect the endogenous analyte.

Effect of Heparin Administration during Coronary Angiography on Vascular or Peripheral Complications: A Single-Blind Randomized Controlled Clinical Trial.

Background: Coronary angiography consists of the selective injection of contrast agents in coronary arteries. Optimal strategy for heparin administration during coronary angiography has yet to be determined. We assessed the effect of heparin administration during coronary angiography on vascular, hemorrhagic, and ischemic complications.

Spatial organization of the cell cytoplasm by position-dependent phase separation.

During asymmetric cell division, cytoplasmic components are segregated to opposite sides of the cell. We discuss how the observed segregation can be achieved by a position-dependent phase separation mechanism controlled by a protein concentration gradient. We show that effects of even a weak gradient can be amplified by the phase transition to achieve strong segregation.

Using Poisson marginal models for investigating the effect of factors on interictal epileptiform discharge in patients with epilepsy.

Background: Epilepsy is a common, chronic neurological disorder that affects more than 40 million people worldwide. Epilepsy is characterized by interictal and ictal functional disturbances. The presence of interictal epileptiform discharges (IEDs) can help to confirm a clinical diagnosis of epilepsy, and their location and characteristics can help to identify the epileptogenic zone or suggest a particular epilepsy syndrome.

Behavioural and histopathological assessment of the effects of periodic fasting on pentylenetetrazol-induced seizures in rats.

Objectives: Periodic fasting (PF) was suggested to display antiepileptic and neuroprotective effects, which is in stark contrast to severe fasting or starvation. However, these beneficial effects seem to depend on the type and duration of the used feeding protocol. There are discrepancies concerning both antiepileptic and neuroprotective effects of a PF-diet during repetitive seizures in different epilepsy models.

Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy.

Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing responses to GABA. In the current pilot study we provide the first documented look at efficacy of bumetanide, a specific NKCC1 antagonist, on reduction of seizure frequency in adult patients with temporal lobe epilepsy.

Prevalence of candida albicans in dental plaque and caries lesion of early childhood caries (ECC) according to sampling site.

Background: Candida albicans may have cariogenic potential but its role in caries etiology has not been established. The aim of this study was to determine candida albicans in supragingival dental plaque and infected dentine of cervical and proximal in early childhood caries (ECC).

Methods: This cross-sectional study was carried out on 6o children aged 2-5 years, which were divided into 3 groups: children with at least one cervical caries; children with at least one proximal caries and caries-free.

Is reducing ovarian volume in polycystic ovarian syndrome patients after administration of metformin associated with improving cardiovascular risk factors?

Background: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular (CV) and metabolic disorders. There is a close relationship between elevated androgen plasma levels and the ultrasound findings of stromal hypertrophy. In randomized trials, the administration of metformin has been shown to be followed by an improvement in insulin sensitivity and decrease in androgen levels in most women.

Centrosome size sets mitotic spindle length in Caenorhabditis elegans embryos.

Just as the size of an organism is carefully controlled, the size of intracellular structures must also be regulated. The mitotic spindle is a supramolecular machine that generates the forces which separate sister chromatids during mitosis. Although spindles show little size variation between cells of the same type, spindle length can vary at least 10-fold between different species.

Germline P granules are liquid droplets that localize by controlled dissolution/condensation.

In sexually reproducing organisms, embryos specify germ cells, which ultimately generate sperm and eggs. In Caenorhabditis elegans, the first germ cell is established when RNA and protein-rich P granules localize to the posterior of the one-cell embryo. Localization of P granules and their physical nature remain poorly understood.

Spectrogoniometer for measuring planetary surface materials at small phase angles.

The surfaces of airless bodies exhibit an anomalous increase in brightness as their faces become fully illuminated to the observer. This opposition effect is generally explained as the disappearance of mutual shadowing among the particles of the optically active portion of the regolith. Models suggest that the regolith's porosity and albedo are the primary factors which determine the effect's amplitude and angular dependence.