Publications by authors named "Joe de Keizer"
Background: Data on the relationship between potassium intake and major cardiovascular events (MACE) in patients with diabetes are scarce. We aim to study the association between estimated potassium intake and risk of MACE in individuals with type 2 diabetes.
Methods: The discovery cohort consisted of 1572 participants with type 2 diabetes from a secondary hospital.
Aim: The use of vitamin K antagonists (VKAs) may increase the risk of peripheral arterial disease (PAD) because vitamin K is a strong inhibitor of medial arterial calcification. Type 2 diabetes (T2D) exposes patients to an increased risk of PAD. We examined how the use of VKAs modulates the risk of incident PAD in people with T2D.
View Article and Find Full Text PDFBackground: One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment.
Research Question: What are the most relevant changes in CT scan parameters over time for assessing response to treatment?
Study Design And Methods: In this ancillary study of a randomized clinical trial (NebuLamB), patients with asthma with available CT scan and without exacerbation during a 4-month allergic bronchopulmonary aspergillosis exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT scan parameters were assessed by systematic analyses of CT scan findings at initiation and end of treatment.
Aims/hypothesis: Type 2 diabetes is associated with a high risk of sudden cardiac death (SCD), but the risk of dying from another cause (non-SCD) is proportionally even higher. The aim of the study was to identify easily available ECG-derived features associated with SCD, while considering the competing risk of dying from non-SCD causes.
Methods: In the SURDIAGENE (Survie, Diabete de type 2 et Genetique) French prospective cohort of individuals with type 2 diabetes, 15 baseline ECG parameters were interpreted among 1362 participants (mean age 65 years; HbA 62±17 mmol/mol [7.
Article Synopsis
- Diabetes significantly increases the risk of cardiovascular diseases, particularly among individuals with type 2 diabetes (T2D), where circulating monocytes play a crucial role in inflammation related to both diabetes and atherosclerosis.* -
- A study involving 672 T2D patients found a positive correlation between blood monocyte counts and coronary artery calcium scores, which are indicators of cardiovascular risk, revealing distinct monocyte subtypes associated with varying cardiovascular risk levels.* -
- The research indicates that analyzing monocyte frequency and profiles can serve as valuable predictors for cardiovascular events in T2D patients, highlighting potential mitochondrial dysfunction in these individuals' immune responses.*
Maternal, Fetal and Neonatal Outcomes Related to Recreational Cannabis Use during Pregnancy: Analysis of a Real-World Clinical Data Warehouse between 2010 and 2019.
Int J Environ Res Public Health
August 2023
Article Synopsis
- - The study examined the effects of recreational cannabis use during pregnancy on adverse outcomes using data from Poitiers University Hospital from 2010 to 2019.
- - Pregnant women using cannabis had characteristics such as being younger, having a lower pre-pregnancy BMI, and a higher psychiatric history compared to those using only tobacco or not using either substance.
- - Results showed that cannabis use was linked to increased risks of pregnancy complications including voluntary interruptions, adverse events during pregnancy, and issues like prematurity and low birth weight.
Background: Spontaneous-breathing trials can be performed with the use of either pressure-support ventilation (PSV) or a T-piece. Whether PSV trials may result in a shorter time to tracheal extubation than T-piece trials, without resulting in a higher risk of reintubation, among patients who have a high risk of extubation failure is unknown.
Methods: In this multicenter, open-label trial, we randomly assigned patients who had a high risk of extubation failure (i.
Article Synopsis
- The study examines the effectiveness of high-flow nasal cannula oxygen compared to standard oxygen in reducing mortality and the need for intubation in COVID-19 patients experiencing respiratory failure in ICUs.
- Conducted across 34 ICUs in France, the SOHO-COVID trial involved 711 patients, randomly assigned to receive either high-flow oxygen or standard oxygen.
- Results showed no significant difference in mortality rates at day 28 between the two groups, with 10% mortality for high-flow and 11% for standard oxygen, suggesting both methods are similarly effective.
Background: Ventilator-associated pneumonia (VAP) is the most frequent health care-associated infection in severely ill patients, and aspiration of contaminated oropharyngeal content around the cuff of the tracheal tube is the main route of contamination.
Research Question: Is continuous regulation of tracheal cuff pressure using a pneumatic device superior to manual assessment three times daily using a portable manometer (routine care) in preventing VAP in patients with severe trauma?
Study Design And Methods: In this open-label, randomized controlled superiority trial conducted in 13 French ICUs, adults (age ≥ 18 years) with severe trauma (Injury Severity Score > 15) and requiring invasive mechanical ventilation for ≥ 48 h were enrolled. Patients were randomly assigned (1:1) via a secure Web-based random number generator in permuted blocks of variable sizes to one of two groups according to the method of tracheal cuff pressure control.