Publications by authors named "Joe Vanderburgh"
Article Synopsis
- Lipid nanoparticles (LNPs) are complex systems that effectively deliver oligonucleotide cargo to cells, but understanding their internal structure at the molecular level is challenging.
- This study introduces a new method using phosphorus nuclear magnetic resonance (NMR) to analyze the structure and dynamics of the phospholipid layer in LNPs, focusing on distearoylphosphatidylcholine (DSPC).
- The developed analytical protocol for measuring phosphorus chemical shift anisotropy (CSA) can be applied in both solution and solid-state NMR, making it versatile for evaluating the properties and stability of LNPs and similar delivery systems.
