Publications by authors named "Joe Tellez"
Background: Increasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, such as tyrosine kinase inhibitors (TKIs). We hypothesized that TKIs would have differential effects on CSC populations depending on their mechanism of action (anti-proliferative vs.
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- The bioethics of in utero gene therapy (IUGT) raises concerns about unintentional genetic changes to the germline that could affect future generations.
- Despite assumptions that the male germline is protected, research shows that germ cells in fetal sheep can be affected by retrovirus-mediated IUGT, highlighting the importance of timing in the procedure.
- The study found that germ cells were transduced at all stages of fetal development, with the highest risk occurring during a specific period of active growth, indicating that later IUGT procedures could reduce this risk.
The recent observation of vector sequences in the semen of men undergoing clinical gene therapy for hemophilia has highlighted the need to evaluate the risk of inadvertent germ-line transduction in a clinically relevant animal model. In the present study, we used three different approaches to investigate whether the germ line is at risk of inadvertent alteration following in utero retroviral gene transfer in the clinically relevant, random-bred sheep model. First, we conducted breeding studies.
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