Publications by authors named "Joe T Roland"
Proc Natl Acad Sci U S A
March 2024
Article Synopsis
- Intestinal expression of claudin-2, a tight junction protein, is linked to increased permeability and is significantly upregulated in septic patients and mice.
- In experiments with claudin-2 knockout mice, the absence of this protein led to reduced inflammation, lower immune cell counts, and decreased intestinal damage during sepsis.
- Deleting claudin-2 not only improved survival rates in septic mice but also mitigated harmful microbial changes, indicating its potential as a therapeutic target in treating septic patients.
