Effects of repeated-dose isradipine on the abuse liability of cocaine.

Despite preclinical studies suggesting that isradipine may antagonize the abuse liability of cocaine, pretreatment with sustained-release isradipine did not reduce euphoric mood in cocaine-using volunteers. This double-blind, within-subject, crossover laboratory study determined whether maximal dose-loading with isradipine could antagonize effects of cocaine in 12 cocaine-dependent research volunteers administered intravenous cocaine doses (0, 0.325, and 0.

Increasing physician impact on the prevention of domestic violence.

Physicians in their professional organizations have recognized the tremendous toll of domestic violence on the safety and health of their patients. Effective integration of screening and referral into routine practice has encountered many significant barriers, primarily the syndrome of compassion fatigue. This article describes how physicians can enhance the safety of families.

A Retrospective Study of Maintenance Electroconvulsive Therapy in a University-Based Psychiatric Practice.

We reviewed the log book of our university-based electroconvulsive therapy (ECT) service for the years 1981 to 1987. We identified 10 patients treated with monthly maintenance electroconvulsive therapy (ECT-M). These 10 patients received 3% of the ECT treatments given in this 7 year period.