The singapore 5-Fluorouracil trabeculectomy study: effects on intraocular pressure control and disease progression at 3 years.

Purpose: To report 3-year results of a randomized, controlled trial comparing the use of a single application of 5-fluorouracil (5-FU) with placebo in trabeculectomy surgery.

Design: Prospective, randomized, double-blinded treatment trial.

Participants: Two hundred forty-three Asian patients with primary open-angle or primary angle-closure glaucoma undergoing primary trabeculectomy.

Effect of trabeculectomy on lens opacities in an East Asian population.

Objective: To examine the progression of lens opacity in Asian people after trabeculectomy and determine associated risk factors.

Methods: This was an observational case series of 243 people aged 36 to 82 years. Trabeculectomy was performed on 1 eye of each subject.

Ocular biometry and refraction in Mongolian adults.

Objective: To describe the variation in ocular biometry and its association with refraction in adult Mongolians.

Methods: The study included 1800 subjects, aged 40 years or more, who were selected in two Mongolian provinces-Hövsgöl and Omnögobi-to participate in this population survey. Axial length (AL) and its components, as well as noncycloplegic autorefraction and corneal power (CP), were measured.

Optic disc hemorrhage in Asian glaucoma patients.

Purpose: To assess the prevalence of optic disc hemorrhage in Asian patients with established glaucoma using a recently described, highly sensitive detection method.

Materials And Methods: Patients entering a trial of glaucoma filtering surgery in Southeast Asia (The Singapore 5FU Study) were assessed for the presence or absence of optic disc hemorrhage using stereo flicker chronoscopy of stereophotograph pairs.

Results: A total of 167 patients (117 males and 50 females) were assessed, of whom 128 were Chinese.

Ultrasonographic biomicroscopy, Scheimpflug photography, and novel provocative tests in contralateral eyes of Chinese patients initially seen with acute angle closure.

Objectives: To compare ocular biometry of the contralateral eyes of individuals seen with acute angle closure (AAC) with eyes of population-based control subjects, and to assess novel provocative tests to study the mechanism of AAC.

Design: Prospective case-control study.

Participants: Chinese persons seen as incident cases of AAC and Chinese population-based controls.

A prospective ultrasound biomicroscopy evaluation of changes in anterior segment morphology after laser iridotomy in Asian eyes.

Purpose: To prospectively quantify changes in anterior segment morphology after laser iridotomy using gonioscopy and ultrasound biomicroscopy (UBM).

Design: Prospective comparative observational case series.

Participants: Fifty-five fellow eyes of patients presenting with acute primary angle closure (APAC).

The severity and spatial distribution of visual field defects in primary glaucoma: a comparison of primary open-angle glaucoma and primary angle-closure glaucoma.

Objective: To compare the characteristics of visual field defects in primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG).

Methods: Subjects with primary glaucoma aged 30 years and older were prospectively considered for inclusion. Automated static white-on-white perimetry was performed.