Publications by authors named "Joe D Joiner"
Article Synopsis
- Histones are crucial for organizing DNA and regulating gene expression, forming different structures in eukaryotes (octamers in nucleosomes) and archaea (dimers in hypernucleosomes).
- The study focuses on a bacterial histone called HBb, which is vital for the survival of Bdellovibrio bacteriovorus and shows unique characteristics in DNA binding compared to eukaryotic and archaeal histones.
- HBb is capable of bending and compacting DNA in a way that is not dependent on specific sequences, indicating that bacterial histones share some similarities with, but also differ significantly from, histones in other life forms.
The emergence of new proteins is a central question in biology. Most tertiary protein folds known to date appear to have an ancient origin, but it is clear from bioinformatic analyses that new proteins continuously emerge in all organismal groups. However, there is a paucity of experimental data on new proteins regarding their structure and biophysical properties.
View Article and Find Full Text PDFThe expression of virulence factors essential for the invasion of host cells by Salmonella enterica is tightly controlled by a network of transcription regulators. The AraC/XylS transcription factor HilD is the main integration point of environmental signals into this regulatory network, with many factors affecting HilD activity. Long-chain fatty acids, which are highly abundant throughout the host intestine, directly bind to and repress HilD, acting as environmental cues to coordinate virulence gene expression.
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