Publications by authors named "Jody-Ann McLeggon"
Article Synopsis
- This study compares the cardiovascular effectiveness of different second-line antihyperglycemic agents (SGLT2 inhibitors, GLP-1 receptor agonists, DPP-4 inhibitors, and sulfonylureas) in patients with type 2 diabetes and cardiovascular disease.
- Using data from over 1.4 million patients across multiple databases, the researchers analyzed the risk of major adverse cardiovascular events (MACE) over a follow-up period of several years.
- Results indicated that SGLT2 inhibitors and GLP-1 receptor agonists had significantly lower risks of MACE compared to DPP-4 inhibitors and sulfonylureas, pointing to their potential superiority as treatment options for
Article Synopsis
- The study aimed to evaluate how often kidney failure occurs in patients receiving intravitreal anti-VEGF treatments and to compare the risks associated with three specific drugs: ranibizumab, aflibercept, and bevacizumab.
- Researchers conducted a retrospective cohort study, analyzing data from 12 databases within the OHDSI network, focusing on patients over 18 with retinal diseases receiving these treatments.
- Results showed an average incidence of kidney failure of 678 per 100,000 persons, and no significant differences in risk were found among the three anti-VEGF drugs, indicating similar safety profiles regarding kidney health.
Background: The Observational Health Data Sciences and Informatics (OHDSI) community has emerged as a leader in observational research on real-world clinical data for promoting evidence for healthcare and decision-making. The community has seen rapid growth in publications, citations, and the number of authors. Components of its successful uptake have been attributed to an open science and collaborative culture for research and development.
View Article and Find Full Text PDFComparative Effectiveness of Second-line Antihyperglycemic Agents for Cardiovascular Outcomes: A Large-scale, Multinational, Federated Analysis of the LEGEND-T2DM Study.
medRxiv
February 2024
Article Synopsis
- * The study analyzed data from over 1.4 million patients treated with various second-line diabetes medications, using advanced statistical methods to compare outcomes and risks of heart issues.
- * Findings indicated that both SGLT2 inhibitors and GLP-1 receptor agonists reduce the risk of cardiovascular events compared to DPP-4 inhibitors and sulfonylureas, but no significant differences were found between SGLT2is and GLP1-RAs themselves regarding heart risks.
Article Synopsis
- Postmarket safety surveillance is crucial for mass vaccination programs, but traditional methods face challenges like multiple testing issues and data biases, leading to the need for improved approaches.
- The researchers developed a Bayesian surveillance method that utilizes negative control outcomes to reduce bias and offers increased flexibility in analyzing vaccine-related adverse events.
- Their empirical evaluation, using data from over 360 million patients, showed that this new method significantly outperformed the existing MaxSPRT approach by reducing Type 1 errors and improving estimation accuracy, with all findings made publicly accessible via an R ShinyApp.
Electronic health records (EHRs) may help enable reliable, rapid data management for many uses, such as facilitating communication of advance care planning (ACP). However, issues with validity and accuracy of EHRs hinder the use of ACP information for practical applications. We present a cross-sectional pilot study of 433 older adults with cancer from three large health care systems, participating in an ongoing multisite pragmatic trial (4UH3AG060626-02).
View Article and Find Full Text PDFObjective: Young adult (YA) cancer survivors who received gonadotoxic therapy are at risk for impaired fertility and/or childbearing difficulties. This study explored the experiences and financial concerns of survivors pursuing family building through assisted reproductive technology (ART) and adoption.
Methods: Retrospective study of data collected from grant applications for financial assistance with family building.
Mortality and Hospitalizations in Intensive Dialysis: A Systematic Review and Meta-Analysis.
Can J Kidney Health Dis
January 2018
Background: Survival and hospitalization are critically important outcomes considered when choosing between intensive hemodialysis (HD), conventional HD, and peritoneal dialysis (PD). However, the comparative effectiveness of these modalities is unclear.
Objective: We had the following aims: (1) to compare the association of mortality and hospitalization in patients undergoing intensive HD, compared with conventional HD or PD and (2) to appraise the methodological quality of the supporting evidence.