Results from a Prospective, Open-Label, Phase 4 Pilot Study of Repository Corticotropin Injection for Moderate and Severe Dry Eye Disease.

Introduction: There is a substantial unmet need for effective therapies to treat patients with refractory dry eye disease (DED). The goal of this open-label pilot study was to investigate the efficacy and safety of repository corticotropin injection (RCI; Acthar® Gel; Mallinckrodt Pharmaceuticals) in subjects with DED, most of whom did not experience adequate response to standard-of-care therapies.

Methods: Adults with moderate or severe-acute DED received 80 U of subcutaneous RCI twice weekly for 12 weeks.

Biofilm Inhibition and Antiviral Response of Cold Sprayed and Shot Peened Copper Surfaces: Effect of Surface Morphology and Microstructure.

Antibacterial properties of copper against planktonic bacteria population are affected by surface microstructure and topography. However, copper interactions with bacteria in a biofilm state are less studied. This work aims at better understanding the difference in biofilm inhibition of bulk, cold-sprayed, and shot-peened copper surfaces and gaining further insights on the underlying mechanisms using optical and scanning electron microscopy to investigate the topography and microstructure of the surfaces.

Cold Spray: Over 30 Years of Development Toward a Hot Future.

Cold Spray (CS) is a deposition process, part of the thermal spray family. In this method, powder particles are accelerated at supersonic speed within a nozzle; impacts against a substrate material triggers a complex process, ultimately leading to consolidation and bonding. CS, in its modern form, has been around for approximately 30 years and has undergone through exciting and unprecedented developmental steps.

Intermetallic Phase Evolution of Cold-Sprayed Ni-Ti Composite Coatings: Influence of As-Sprayed Chemical Composition.

Owing to low-temperature deposition conditions and high deposition rate, cold spray offers unique advantages in manufacturing a wide variety of metallic and composite coatings including metal matrix composites produced from physically blended powders. One of the challenges of producing composite coatings using cold spray is the deviation of coatings composition from the blended feedstock powder composition. This is of utmost importance as it affects the composition and phase evolution of intermetallic forming coatings during post spray heat treatment.