The Wales Cancer Research Centre: improving cancer care together.

The Wales Cancer Research Centre (WCRC), funded by the Welsh Government, through Health and Care Research Wales, is our latest weapon in the ongoing war against cancer. It is Wales' contribution to a global effort to reverse the increasing trend in numbers of newly diagnosed cancers. With the increasing need for new and better cancer treatments, more research is needed, and the WCRC hopes to fulfill some of this demand.

Maternal dietary intake in twin pregnancies: does it diminish towards term?

We tested the hypothesis that energy intake among women with twin pregnancies decreases in late gestation, as the uterus enlarges and they become increasingly uncomfortable. We asked women to recall dietary intake for the previous 24 hours, every 2 weeks from around 29 weeks of gestation, using a photographic atlas and other strategies to estimate portion size. Eighty women provided data at around 29, 31, 33 and 35 weeks of gestation.

Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression.

Background: Despite the widespread use of megestrol acetate (MA) among a growing number of pediatric oncology departments, there is only one published study on the use of MA in children with malignant disease. The objectives of the current study were to examine the effect of MA in improving the nutritional status of children with malignant disease and to describe and consider the implications of MA-associated adrenal suppression that was found consistently.

Methods: Medical records of 19 children with malignant disease who were treated with MA were reviewed.