Publications by authors named "Jodi Wilkowski"

Article Synopsis
  • Retroperitoneal and abdominopelvic sarcomas are rare tumors where only complete surgical resection (R0/R1) has been shown to improve disease-free survival (DFS).
  • A study reviewed 159 adult patients who underwent surgery for these sarcomas, focusing on whether additional treatments like radiation and systemic therapy impacted their DFS and abdominal recurrence-free survival (RFS).
  • Results indicated that neoadjuvant (pre-surgery) radiation improved DFS and RFS significantly, while systemic therapy did not show any benefit, although patients needed a minimum follow-up of three years to assess differences in outcomes.
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Background: Lipoleiomyoma is a rare, benign variant of the commonplace uterine leiomyoma. Unlike leiomyoma, these tumors are composed of smooth muscle cells admixed with mature adipose tissue. While rare, they are most frequently identified in the uterus, but even more infrequently have been described in extrauterine locations.

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Finding the causative genetic variations that underlie complex adult traits is a significant experimental challenge. The unbiased search strategy of genome-wide association (GWAS) has been used extensively in recent human population studies. These efforts, however, typically find only a minor fraction of the genetic loci that are predicted to affect variation.

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Epigenetic control of gene expression is a consistent feature of differentiated mammalian cell types. Epigenetic expression patterns are mitotically heritable and are stably maintained in adult cells. However, unlike somatic DNA mutation, little is known about the occurrence of epigenetic change, or epimutation, during normal adult life.

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