Publications by authors named "Jochen Martin Wettengel"
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain unclear. Using optical clearing and imaging, we observed the accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients, persisting long after viral clearance. Further, biomarkers of neurodegeneration were elevated in the cerebrospinal fluid from long COVID patients, and proteomic analysis of human skull, meninges, and brain samples revealed dysregulated inflammatory pathways and neurodegeneration-associated changes.
View Article and Find Full Text PDFIn this study, we analyzed norovirus (NoV) evolution in sequential samples of six chronically infected patients. The capsid gene was amplified from stool samples, and deep sequencing was performed. The role of amino acid flexibility in structural changes and ligand binding was studied with molecular dynamics (MD) simulations.
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- Chronic hepatitis B virus (HBV) infections often lead to liver cancer (HCC) due to persistent virus and weak immune response, necessitating new treatments to restore antiviral immunity.
- Researchers developed bispecific T-cell engager antibodies that activate T-cells against HBV-infected liver cells by targeting HBV envelope proteins, boosting both direct killing and cytokine-mediated control of the virus.
- In mouse models, these antibodies successfully directed T-cell responses towards HBV-infected tumors, reducing tumor size and demonstrating potential as a new treatment for chronic hepatitis B and related liver cancer.
Noroviruses (NoV) cause the majority of non-bacterial gastroenteritis cases worldwide, with genotype II.4 being the most common. The aim of our study was to quantitate norovirus-specific IgG in immunocompromised patients before and after laboratory-confirmed norovirus infection.
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