Publications by authors named "Jochen F Kuebler"
Article Synopsis
- T-cells play a significant role in ischemia-reperfusion injury (IRI) across various organs, with γδ-T-cells having a unique capacity for rapid immune response.
- Research examined the function of γδ-T-cells in intestinal IRI using wild-type and γδ-T-cell-deficient mice, focusing on inflammation markers and organ injury.
- Results showed that γδ-T-cell deficiency reduced inflammation and distant organ injury, suggesting these cells could be key mediators in the inflammatory response during acute intestinal IRI.
Background: Infants undergoing general anaesthesia have an increased risk of severe respiratory and cardiovascular critical events. Awake caudal anaesthesia is an alternative for small infants undergoing minor lower abdominal surgery. While clinical experience has shown stable intra-operative haemodynamic conditions, there are no studies evaluating systemic and regional cerebral perfusion during such a procedure.
View Article and Find Full Text PDFPurpose: Ischemia-reperfusion injury (IRI) is associated with significant patient mortality and morbidity. The complex cascade of IRI is incompletely understood, but inflammation is known to be a key mediator. In addition to the predominant innate immune responses, previous research has also indicated that αβ T cells contribute to IRI in various organ models.
View Article and Find Full Text PDFBackground: Biliary atresia (BA) is the most common indication for liver transplantation in children. The experimental model of BA, induced by rotavirus infection in neonatal mice, has been widely used to investigate the inflammatory aspects of this disease. We investigated the kinetics and the localization of the viral infection in this murine model.
View Article and Find Full Text PDFPurpose: Laparoscopy has been associated with lower inflammatory responses. However, it has been postulated that minilaparotomy, in contrast to full laparotomy, is equally minimally invasive.
Objective: The aim of this study was to investigate local, systemic, and distant organ immune responses after different surgical approaches to the abdominal cavity, such as minilaparotomy, full laparotomy, and laparoscopy, in a small animal model.