Publications by authors named "Jochem Stormmesand"
Article Synopsis
- Women exhibit a higher prevalence of Alzheimer's disease (AD) compared to men, potentially linked to lowered estrogen levels during aging; the study investigates the role of the transcription factor EGR1 in this context.
- Female 3xTg-AD mice showed elevated β-amyloid (Aβ) levels without significant differences in hyperphosphorylated tau (p-Tau) compared to males, while in cultured cells, estrogen (E2) decreased extracellular Aβ and increased levels of EGR1 and AChE.
- The findings suggest that the 3xTg-AD mouse model can help understand sex differences in AD, highlighting the protective effects of local estrogen in supporting EGR1 and cholinergic function while potentially reducing
Aims: Women are more vulnerable to Alzheimer's disease (AD) than men. We investigated (i) whether and at what age the AD hallmarks, that is, β-amyloid (Aβ) and hyperphosphorylated Tau (p-Tau) show sex differences; and (ii) whether such sex differences may occur in cognitively intact elderly individuals.
Methods: We first analysed the entire post-mortem brain collection of all non-demented 'controls' and AD donors from our Brain Bank (245 men and 403 women), for the presence of sex differences in AD hallmarks.
The locus coeruleus (LC) has been studied in major depressive disorder (MDD) and bipolar disorder (BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown pigment neuromelanin. Here, we used a multispectral method to untangle the two colors: blue immunocytochemical staining and brown neuromelanin.
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