Outpatient High-dose Methotrexate for Osteosarcoma: It's Safe and Feasible, If You Want It.

Background: High-dose methotrexate (HD MTX) is usually administered as an inpatient to those with osteosarcoma. We prospectively tested the safety and feasibility of administering HD MTX in the ambulatory setting.

Materials And Methods: In this single arm prospective observational study, eligible patients had previously completed 2 courses of HD MTX as an inpatient.