Publications by authors named "Jocelyn Cervantes"
Article Synopsis
- SLITs are proteins that act as ligands for ROBO receptors, which are important for cell signaling.
- Research indicates that ROBO1 helps mammary cells differentiate and produce milk by blocking Notch signaling.
- In experiments, knockout mice lacking SLIT2 and SLIT3 showed better development of milk-producing cells and higher milk production, suggesting that SLITs inhibit this process by interfering with ROBO1.
Article Synopsis
- - Diabetes significantly raises the risk of heart and kidney diseases, particularly highlighting that those with kidney disease face even higher cardiovascular risks.
- - The study found that higher levels of apolipoprotein C3 (APOC3) in patients with type 2 diabetes predict worse kidney function, suggesting it plays a role in diabetic kidney disease and atherosclerosis.
- - By silencing APOC3 in diabetic mice, researchers observed reduced kidney damage and atherosclerosis, indicating that targeting APOC3 could be a promising strategy for treating these diabetes-related complications.
Monocyte and macrophage foam cells in diabetes-accelerated atherosclerosis.
Front Cardiovasc Med
June 2023
Diabetes results in an increased risk of atherosclerotic cardiovascular disease. This minireview will discuss whether monocyte and macrophage lipid loading contribute to this increased risk, as monocytes and macrophages are critically involved in the progression of atherosclerosis. Both uptake and efflux pathways have been described as being altered by diabetes or conditions associated with diabetes, which may contribute to the increased accumulation of lipids seen in macrophages in diabetes.
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