Publications by authors named "Jobanpreet Sehmi"
Article Synopsis
- The study focuses on developing and validating an open machine-learning method for calculating Global Longitudinal Strain (GLS), which is deemed more reliable than traditional measures like ejection fraction.
- Using a neural network trained on over 6,800 echocardiogram images, researchers were able to accurately identify key cardiac landmarks and compute GLS values.
- The open-source methodology demonstrated comparable accuracy to expert measurements and proprietary solutions, with data and resources available freely online for further research.
Background: requires training and validation to standards expected of humans. We developed an online platform and established the Unity Collaborative to build a dataset of expertise from 17 hospitals for training, validation, and standardization of such techniques.
Methods: The training dataset consisted of 2056 individual frames drawn at random from 1265 parasternal long-axis video-loops of patients undergoing clinical echocardiography in 2015 to 2016.
Article Synopsis
- Researchers analyzed genetic data from over 39,000 people to find new associations linked to glycemic traits and type 2 diabetes risk.
- They discovered a specific variant (p.Pro50Thr) that increases fasting plasma insulin levels by 12%, particularly in individuals of Finnish descent.
- This variant is associated with lower insulin sensitivity and a slightly higher risk of developing type 2 diabetes, highlighting its functional impact in glucose regulation.
Background: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death.
View Article and Find Full Text PDFObjective: The chemokine CXCL16 serves as a scavenger receptor for oxidized low-density lipoprotein and as an adhesion molecule and chemoattractant for cells expressing the receptor CXCR6. A commonly occurring CXCL16 allele has been described containing 2 nonsynonymous single-nucleotide polymorphisms in complete linkage disequilibrium, although the effects on CXCL16 function are unknown. Here, we examined the effect of the single-nucleotide polymorphisms on CXCL16 function and assessed the association of the mutant allele with coronary heart disease (CHD).
View Article and Find Full Text PDFObjective: To quantify the variability in the concentration of drug infusions prepared on an intensive care unit and establish whether there was a relationship between the quality of syringe labeling and drug preparation.
Design: Audit carried out over 3 weeks in May 2006 and completed in May 2007.
Setting: The adult neurosciences critical care unit of a UK university teaching hospital.