Publications by authors named "Joar Franzen"

Article Synopsis
  • The Correa's cascade outlines a pathway for non-cardia gastric cancer development, starting from chronic non-atrophic gastritis and progressing to dysplasia.
  • A study involving over 300,000 patients undergoing endoscopy identified higher mortality rates among gastric lesion subgroups, with the highest risk seen in those with dysplasia (SMR of 1.54).
  • Cause-specific mortality from gastric cancer was significantly elevated at each stage of the cascade, with dysplasia patients experiencing over 600% increased risk, alongside heightened risks from other diseases compared to the general population.
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Background: The association between atrophic gastritis (AG) and symptomatic gastroesophageal reflux disease (GERD) needs to be better assessed.

Objective: We aimed to study this association in a twin setting, controlling for genetic and familial factors, in addition to a range of known covariates.

Methods: We performed a co-twin control study based on the Swedish Twin Registry, including confirmed monozygotic (MZ) and dizygotic (DZ) twins.

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For targeted eradication of () to reduce gastric cancer burden, a convenient approach is definitely needed. The purpose of this study was to evaluate the LAMP assay for detection using samples collected by noninvasive and self-sampling methods. The available LAMP assay for detection was appraised and verified using reference and clinically isolated strains.

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Keratoacanthomas (KA) and Spitz naevus (SN) are both lesions with unknown aetiology; therefore, the possibility of a viral involvement, more specifically the involvement of human polyomaviruses (HPyV), was investigated. In total, 22 cases of KA and 25 cases of SN were tested for the presence of HPyVs. DNA was extracted and amplified by multiplex PCR and thereafter tested with a multiplex bead-based assay for HPyVs (BKPyV, JCPyV, KIPyV, WUPyV, MCPyV, TSPyV, HPyV6, 7 and 9) and two primate viruses (SV40 and LPyV).

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During 2009-2011, we reported that the oral and cervical prevalence of human papillomavirus (HPV) was high by international standards at 9.3% and 74%, respectively, in youth aged 15-23 years attending a youth clinic in Stockholm. After gradual introduction of public HPV vaccination during 2007-2012, between 2013 and 2014, when 73% of the women were HPV-vaccinated, but not necessarily before their sexual debut, oral HPV prevalence had dropped to 1.

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