Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics.

Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a senescence-associated secretory phenotype macromolecular damage, and metabolic dysregulation. Vascular senescence has been demonstrated to play a key role in different vascular diseases, such as atherosclerosis, peripheral arterial disease, hypertension, stroke, diabetes, chronic venous disease, and venous ulcers.

Impact of repeat ablation of ventricular tachycardia in patients with structural heart disease.

Aims: Recurrences of ventricular tachycardia (VT) after initial catheter ablation is a significant clinical problem. In this study, we report the efficacy and risks of repeat VT ablation in patients with structural heart disease (SHD) in a tertiary single centre over a 7-year period.

Methods And Results: Two hundred ten consecutive patients referred for repeat VT ablation after previous ablation in our institution were included in the analysis (53% ischaemic cardiomyopathy, 91% males, median age 65 years, mean left ventricular ejection fraction 35%).

Modification of the Polymer of a Bone Cement with Biodegradable Microspheres of PLGA and Loading with Daptomycin and Vancomycin Improve the Response to Bone Tissue Infection.

Unlabelled: Chronic infections are one of the most serious adverse outcomes of prosthetic surgery. Prosthetic revision surgery using a bone cement loaded with antibiotics between the two stages of the surgery is commonly performed. However, this method often fails to reach the minimum inhibitory concentration and promotes antibiotic resistance, thus emphasizing the need for improving the current available therapies.

Polylactic-co-glycolic acid microspheres added to fixative cements and its role on bone infected architecture.

Joint prostheses are an essential element to improve quality of life. However, prostheses may fail due to several factors, including the most frequent cause, Staphylococcus aureus infection. The identification of new fixing bone cements with less reactivity on bone tissue and an adequate response to infection remains a primary challenge.

Partially coherent diffraction-free vortex beams with a Bessel-mode structure.

A new family of partially coherent beams carrying optical vortices is introduced. Any member of this family represents an incoherent superposition of fully coherent orthogonal Bessel modes with the same helical wavefront and is notable for its diffraction-free propagation. It is shown analytically and experimentally that such beams can be approximately generated in the Fourier-transforming optical system with a computer-controlled liquid-crystal spatial light modulator.

Simple technique for generating the perfect optical vortex.

We propose an improved technique for generating the perfect optical vortex. This technique is notable for the simplicity of its practical realization and high quality of the results. The efficiency of the proposed technique is illustrated with the results of physical experiments and an example of its application in optical trapping of small particles.