Rescue of streptomycin activity by piperine in .

To evaluate the modulatory effect of piperine (PIP) on streptomycin (SM) activity in (). SM and PIP minimum inhibitory concentration (MIC) and combinatory activity were determined in HRv and in susceptible and resistant clinical isolates. Ethidium bromide accumulation assay and relative quantification of efflux pumps genes ( and ), after SM and SM+PIP combination exposure, were also performed.

Modulatory effects of verapamil in rifampicin activity against Mycobacterium tuberculosis.

Aim: To evaluate modulatory effect of verapamil (VP) in rifampicin (RIF) activity and its effect in efflux pumps (EPs) transcript levels in Mycobacterium tuberculosis.

Materials & Methods: RIF and VP minimal inhibitory concentration, combinatory effect and detection of mutations were determined in 16 isolates. EPs transcript levels were determined in four isolates by real-time PCR after exposure to drugs.