Publications by authors named "Joao Vinicius Honorio da Silva"
Lisdexamfetamine dimesylate-exposition in male rats during the peripubertal period impairs inflammatory mechanisms, antioxidant activity, and apoptosis process in kidneys of male pubertal rats.
J Biochem Mol Toxicol
August 2024
Article Synopsis
- Lisdexamfetamine dimesylate (LDX), a drug for ADHD, hasn't been studied for its potential toxic effects on kidneys, which is the focus of this research.
- The study involved male Wistar rats treated with LDX to assess kidney health through various parameters including cell death, inflammation, and oxidative stress.
- Findings revealed increased cell death and inflammation in the kidneys of LDX-treated rats, but a normal functioning antioxidant system, indicating significant renal changes during the peripubertal period.
Wound infections are feared complications due to their potential to increase healthcare costs and cause mortality since multidrug-resistant bacteria reduce treatment options. This study reports the development of a carbomer hydrogel containing biogenic silver nanoparticles (bioAgNPs) and its effectiveness in wound treatment. This hydrogel showed in vitro bactericidal activity after 2 h, according to the time-kill assay.
View Article and Find Full Text PDFMangiferin: A promising natural xanthone from Mangifera indica for the control of acyclovir - resistant herpes simplex virus 1 infection.
Bioorg Med Chem
February 2020
Mangiferin is found in many plant species as the mango tree (Mangifera indica) with ethnopharmacological applications and scientific evidence. The emergence of resistant herpes simplex virus (HSV) strains to Acyclovir (ACV) has encouraged the search for new drugs. We investigated the in vitro and in vivo activity of mangiferin obtained from M.
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