Publications by authors named "Joao Ronielly Campelo Araujo"
Development of a Nanoformulation for Oral Protein Administration: Characterization and Preclinical Orofacial Antinociceptive Effect.
AAPS PharmSciTech
August 2022
Nanoencapsulation is a valid alternative for the oral administration of peptide drugs and proteins, as nanoparticles protect them from proteolytic degradation in the gastrointestinal tract and promote the absorption of these macromolecules. The orofacial antinociceptive effect of frutalin (FTL), through the intraperitoneal route, has already been proven. This study aimed to develop, characterize, and evaluate the orofacial antinociceptive activity of an oral formulation containing FTL in acute and neuropathic preclinical tests.
View Article and Find Full Text PDFDioclea Altissima Seed Lectin (DAL) Prevents Anxiety-like Behavioral Responses in Adult Zebrafish (Danio Rerio): Involvement of GABAergic and 5-HT Systems.
CNS Neurol Disord Drug Targets
March 2022
Background: Plant lectins have shown promising neuropharmacological activities in animal models.
Objective: This study evaluated the effect of Dioclea altissima seed lectin (DAL) on adult zebrafish behavior.
Method: Zebrafish (n=6/group) were treated (i.
Lectins are proteins or glycoproteins of non-immunological origin capable of reversibly and specifically binding to glycoconjugates. They exist in free form or associated with cells and are widely distributed in nature, being found in plants, microorganisms, and animals. Due to their characteristics and mainly due to the possibility of reversible binding to glycoconjugates, lectins have stood out as important tools in research involving Neurobiology.
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- The study tested the effectiveness of protein extracts from Cassia fistula L. and Combretum leprosum Mart. leaves against goat gastrointestinal parasites.
- The protein preparations were separated into three fractions (F1, F2, F3) and evaluated for their ability to inhibit egg hatching and larval development.
- Results showed Cassia fistula significantly reduced egg hatching and larval development, while Combretum leprosum had little effect, indicating Cassia fistula is a more effective treatment against these parasites.
Neuropharmacological characterization of frutalin in mice: Evidence of an antidepressant-like effect mediated by the NMDA receptor/NO/cGMP pathway.
Int J Biol Macromol
June 2018
In this study we evaluated the effect of frutalin (FTL) on mouse behavior. Mice (n=6/group) were treated (i.p.
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- * Eucalyptol significantly reduced pain responses in various tests involving acute and chronic pain models, with effects showing sensitivity to TRPV1 receptor involvement.
- * The study suggests that eucalyptol could be a useful clinical treatment for orofacial pain by acting as an antagonist to TRPV1 channels, without affecting locomotor activity.