Potassium Persulfate Promoted the One-Pot and Selective -Functionalization of Pyrazoles under Acidic Conditions.

Our research presents selective direct selenylation at the C-4 pyrazole ring using KSO as an oxidant under simple and mild conditions. This elegant synthesis involves the one-pot method under acidic conditions, thus minimizing reaction steps and waste generation. This innovative method allowed us to create a library of 4-selanylpyrazoles in good to excellent yields.

Efficient Synthesis and Iodine-Functionalization of Pyrazoles via KIO/PhSeSePh System under Acidic Conditions.

This manuscript reports a novel method for the direct iodination of the C-4 pyrazole ring generated in situ by the reaction of 1,1,3,3-tetramethoxypropane and various hydrazines. In this approach, potassium iodate (KIO) is used as the iodinating agent and (PhSe) is used as catalysts under acidic conditions. This protocol provides a convenient method for the efficient synthesis of 4-iodo-1-aryl-1H-pyrazoles, valuable intermediates for several different coupling reactions.