Publications by authors named "Joao Paulo Rodrigues Santos"
Detached epithelial cell plugs from the upper respiratory tract favour distal lung injury in Golden Syrian hamsters (Mesocricetus auratus) when experimentally infected with the A.2 Brazilian SARS-CoV-2 strain.
Marcelo Pelajo-Machado Alexandre Dos Santos da Silva Daniela Del Rosario Flores Rodrigues Milla Bezerra Paiva Rodrigo Muller João Paulo Rodrigues Dos Santos
Mem Inst Oswaldo Cruz
October 2024
Background: The Golden Syrian hamster (Mesocricetus auratus), Ferrets (Mustela putorius furo), and macaques have been described as useful laboratory animals naturally susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Objectives: To study the mechanism of lung injury, we describe the histopathological features of SARS-CoV-2 infection in Golden Syrian hamsters inoculated intranasally with the A.2 Brazilian strain.
Hematopoiesis is the process by which blood cells are generated. During embryonic development, these cells migrate through different organs until they reach the bone marrow, their definitive place in adulthood. Around E10.
View Article and Find Full Text PDFPrimary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury.
Arthur da Costa Rasinhas Fernanda Cunha Jácome Gabriela Cardoso Caldas Ana Luisa Teixeira de Almeida Daniel Dias Coutinho de Souza João Paulo Rodrigues Dos Santos Flavia Barreto Dos Santos
Mem Inst Oswaldo Cruz
May 2023
Article Synopsis
- Dengue is caused by four serotypes of the dengue virus (DENV-1 to -4), with DENV-4 being the least understood and often leading to complications like acute kidney injury in severe cases.
- This study aimed to explore how experimental infection with DENV-4 affects kidney tissue in adult BALB/c mice, using intravenous infection and subsequent analysis of the kidneys.
- Findings showed viral presence and significant kidney damage, including inflammation, glomerular enlargement, and necrosis of tubular cells, suggesting that while the kidney may not be a primary target for the virus, it still suffers damage from the infection.