Human papillomavirus infections with multiple types and risk of cervical neoplasia.

Background: Besides an established role for certain human papillomavirus (HPV) genotypes in the etiology of cervical cancer, little is known about the influence of multiple-type HPV infections on cervical lesion risk. We studied the association between multiple HPV types and cervical lesions among 2,462 Brazilian women participating in the Ludwig-McGill study group investigation of the natural history of HPVs and cervical neoplasia.

Methods: Cervical specimens were typed by a PCR protocol.

Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia.

Background: Little is known about the duration of precancerous cervical lesions in relation to human papillomavirus (HPV) infection. We estimated rates of progression and regression and sojourn times of cervical squamous intraepithelial lesions (SILs) according to HPV status.

Methods: We used data from a longitudinal study of HPV infection and cervical neoplasia in São Paulo, Brazil.