Semaglutide restores astrocyte-vascular interactions and blood-brain barrier integrity in a model of diet-induced metabolic syndrome.

Introduction: Metabolic syndrome (MetS) is a metabolic disorder related to obesity and insulin resistance and is the primary determinant of the development of low-intensity chronic inflammation. This continuous inflammatory response culminates in neuroimmune-endocrine dysregulation responsible for the metabolic abnormalities and morbidities observed in individuals with MetS. Events such as the accumulation of visceral adipose tissue, increased plasma concentrations of free fatty acids, tissue hypoxia, and sympathetic hyperactivity in individuals with MetS may contribute to the activation of the innate immune response, which compromises cerebral microcirculation and the neurovascular unit, leading to the onset or progression of neurodegenerative diseases.

Comprehensive Retrospective Analysis of Corneal Donor Characteristics at the National Institute of Traumatology and Orthopedics Eye Bank (2013-2021).

Background: Corneal transplantation success depends on good practices in tissue selection and preservation. This study aimed to assess the relationship between the time from the donor's death to the end of processing and corneal cellularity provided by the Eye Bank.

Methods: This was a retrospective study of 839 donor records (2013-2021) from the Eye Bank of the National Institute of Traumatology and Orthopedics, totaling 1445 corneas.