Trastuzumab-based regimens beyond progression: A crucial treatment option for HER2+ advanced/metastatic breast cancer.

Upon its establishment for the treatment of metastatic breast cancer (mBC), continuing trastuzumab beyond disease progression was an important paradigm shift that became the recommendation by major guidelines. However, data supporting continuation of human epidermal growth factor receptor 2 (HER2) blockade with trastuzumab beyond the second-line setting are limited, resulting in a lack of approval of, or access to, this therapeutic strategy in many countries. This study aimed to provide additional data on the continued use of trastuzumab and trastuzumab-based therapies in combination with chemotherapy (CT) as third-line treatment for patients with mBC.

Characterization of sleep quality in Brazilian Jiu-Jitsu fighters.

Introduction: Sleep quality can positively or negatively influences the physical performance of Brazilian Jiu-Jitsu fighters; however, the literature does not indicate whether the sleep quality of these fighters is good or poor.

Objective: Characterization of the sleep quality of Brazilian Jiu-Jitsu (BJJ) fighters, stratifying by weight category and color belts.

Material And Methods: A descriptive study that featured with 175 BJJ fighters, the Pittsburgh Sleep Quality Index (PSQI) was applied to assess sleep quality.

HOX genes function in Breast Cancer development.

Breast cancer develops in the mammary glands during mammalian adulthood and is considered the second most common type of human carcinoma and the most incident and mortal in the female population. In contrast to other human structures, the female mammary glands continue to develop after birth, undergoing various modifications during pregnancy, lactation and involution under the regulation of hormones and transcription factors, including those encoded by the HOX clusters (A, B, C, and D). Interestingly, HOX gene deregulation is often associated to breast cancer development.