The Influence of Gondeshapur Medicine during the Sassanid Dynasty and the Early Islamic Period.

The development of the most active period of Persian medicine occurred in the ancient city of Gondeshapur, between the third and seventh centuries. Rebuilt between 256 and 260 by Shapur I, the second Sassanid monarch, Gondeshapur is said to have welcomed the first hospital and the consequent study of medicine, mainly based on the Greek system. It has also been mentioned that these teachings would be expanded by his successor, Shapur II.

[Medical education and professionalism].

Is briefly analyzed the evolution that the objectives, strategies and models of medical education have had since their presentation and subsequent implementation of the famous model of Abraham Flexner, is now 103 years. Although globally accepted in their original pedagogical principles and instruments, that model does not have avoided the continuing dissatisfaction by the medical community and students and, most markedly in recent decades, the demanding of a most efficient health care by society, in general, and by patients in particular. In response to these ambitions, the medical community felt that it was essential to review the traditional criteria of medical professionalism, adapting them to a new paradigm of society and an appropriate and more efficient model of medical education.

Expression and subcellular localization of a novel nuclear acetylcholinesterase protein.

Acetylcholine is found in the nervous system and also in other cell types (endothelium, lymphocytes, and epithelial and blood cells), which are globally termed the non-neuronal cholinergic system. In this study we investigated the expression and subcellular localization of acetylcholinesterase (AChE) in endothelial cells. Our results show the expression of the 70-kDa AChE in both cytoplasmic and nuclear compartments.

Effects of choline on hemorheological properties and NO metabolism of human erythrocytes.

Purpose Of The Study: To determine the effects of choline on red blood cell membrane properties and NO metabolism.

Material And Methods: Aliquots of venous blood from eleven healthy subjects were incubated in vitro with choline concentrations 10(-10) to 10(-3) M. The following parameters were determined: erythrocyte deformability, aggregation and membrane lipid fluidity, plasma K+, Na+, Ca2+, total blood haemoglobin and methemoglobin concentrations.

Evidence of prolonged disturbances in the haemostatic, hemorheologic and inflammatory profiles in transmural myocardial infarction survivors.

Haemostatic, hemorheologic and inflammatory disturbances have been associated with acute coronary syndromes. Most knowledge is reported in cross sectional studies and are without time dependent evolution of these profiles. The aim of this study was to evaluate, during the first year, the evolution of the haemostatic, hemorheologic and inflammatory profiles determined at hospital discharge in survivors with transmural myocardial infarction (MI).