Loss of constitutive expression in breast cancer associated with worse prognosis.

gene encodes an adenosine 5'-triphosphate-binding cassette transporter, which not only confers multidrug resistance phenotype in malignant cells, but is also present in several nonmalignant tissues. For the last thirty years, expression in breast cancer has been described by many authors, but the extent of expression differs among the studies, and there is no consensus regarding its potential role in carcinogenesis or in the tumor response to antineoplastic drugs. This study aimed to characterize the expression of in breast tumors as a function of genetic, clinical, and histopathological variables.

Prognostic evaluation of VEGFA genotypes and haplotypes in a cohort of Brazilian women with non metastatic breast cancer.

Vascular Endothelial Growth Factor (VEGF) mediates angiogenesis, which is crucial for tumor development and progression. The present study aimed to evaluate the impact of VEGFA gene polymorphisms rs699947, rs833061, rs1570360, rs2010963 and rs3025039 on breast cancer features and prognosis. A cohort of Brazilian women (N = 1038) with unilateral non-metastatic breast cancer was evaluated.

Effects of Angiotensin, vasopressin and aldosterone on proliferation of mcf-7 cells and their sensitivity to Doxorubicin.

Breast cancer is one of the leading causes of death among women and the renin-angiotensin system (RAS) has been associated with breast tumor growth and metastasis. Inhibition of the RAS limits such effects and several efforts have been made to develop new inexpensive strategies for breast cancer treatment. We herein provide additional evidence that breast cancer chemotherapy can be influenced by losartan and PD123319, antagonists of angiotensin receptors AT1 and AT2, respectively.