Publications by authors named "Joao Marcos G Barbosa"
Recent studies have highlighted the potential of earwax or cerumen, a non-conventional biomatrix, in volatilomics research as a valuable matrix for disease biomarker discovery. Despite that, there are still gaps in using non-conventional biomatrices in metabolomics research. In this sense, this study aimed to elucidate the main analytical factors involved in the extraction and analysis of volatile organic compounds (VOCs) in cerumen by headspace/gas chromatography-mass spectrometry (HS/GC-MS) using Design of Experiments (DoE) approaches.
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- Human cerumen analysis is emerging as a non-invasive method for diagnosing diseases by detecting volatile organic metabolites (VOMs) in earwax, potentially identifying biomarkers for various health conditions.
- A study examined how demographic factors like BMI, sex, age, and ethnicity influence the presence and abundance of these VOMs, using data from 70 volunteers and advanced analysis techniques.
- Results indicated that sex and BMI had a significant effect on VOM abundance, while no clear patterns of discrimination based on demographic factors emerged, highlighting the need for further research in personalized medicine approaches using cerumen analysis.
Background: Cancer is a significant public health problem, causing dozens of millions of deaths annually. New cancer screening programs are urgently needed for early cancer detection, as this approach can improve treatment outcomes and increase patient survival. The search for affordable, noninvasive, and highly accurate cancer detection methods revealed a valuable source of tumor-derived metabolites in the human metabolome through the exploration of volatile organic compounds (VOCs) in noninvasive biofluids.
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- Bovine laminitis is a significant health issue in dairy and beef farms, leading to welfare and economic challenges, but its underlying metabolic and inflammatory causes are not well understood, complicating diagnostic efforts.
- This study develops a non-invasive veterinary cerumenomic assay using earwax metabolites to effectively identify bovine laminitis through advanced gas chromatography and mass spectrometry techniques.
- The findings highlight specific volatile metabolites, such as p-cresol and formamide, as potential biomarkers for diagnosing bovine laminitis, showcasing promising diagnostic accuracy and paving the way for earlier detection in affected cattle.
Article Synopsis
- Cancer is a major threat to both humans and dogs, often progressing quickly in canines, highlighting the need for early detection methods.!
- Researchers tested earwax (cerumen) as a potential source of cancer biomarkers by analyzing samples from dogs with tumors and healthy dogs using advanced gas chromatography techniques.!
- Their findings identified 18 volatile metabolites that can accurately distinguish between dogs with tumors and healthy ones, achieving a diagnostic accuracy of 95%, making this method a promising non-invasive option for veterinary cancer diagnosis.!
Introduction: Trypanosomiasis caused by Trypanosoma vivax (T. vivax, subgenus Duttonella) is a burden disease in bovines that induces losses of billions of dollars in livestock activity worldwide. To control the disease, the first step is identifying the infected animals at early stages.
View Article and Find Full Text PDFAn innovative volatolomic approach employs the detection of biomarkers present in cerumen (earwax) to identify cattle intoxication by Stryphnodendron rotundifolium Mart., Fabaceae (popularly known as barbatimão). S.
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