March1-dependent modulation of donor MHC II on CD103 dendritic cells mitigates alloimmunity.

In transplantation, donor dendritic cells (do-DCs) initiate the alloimmune response either by direct interaction with host T cells or by transferring intact donor MHC to host DCs. However, how do-DCs can be targeted for improving allograft survival is still unclear. Here we show CD103 DCs are the major do-DC subset involved in the acute rejection of murine skin transplants.