The Influence of Fatty Acid Oxygenases PpoA and PpoC on Caspofungin Susceptibility.

can cause invasive pulmonary aspergillosis (IPA). Fungicidal azoles and fungistatic caspofungin (CAS) are the first- and second-line therapies, respectively, used to treat IPA. Treatment of with CAS or micafungin induces the production of the oxylipin 5,8-diHODE by the fungal oxygenase PpoA.