Acetogenins-Rich Fractions of Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro.

Glioblastoma (GBM) is an incurable primary brain tumor with a poor prognosis. Resection, radiation therapy, and temozolomide (TMZ) are insufficient to increase survival, making the treatment limited. Thus, the search for more effective and specific treatments is essential, making plants a promising source for elucidating new anti-glioblastoma compounds.

Qualitative analysis of the acetogenins from (Annonaceae) leaves by HPLC-Q-Orbitrap and their antibacterial potential against oral pathogens.

Araticum is an edible and appreciable fruit of , which is popularly known as a traditional herb in the Brazilian cerrado. A phytochemical study from the leaves of showed that HPLC-ESI-Q-Orbitrap® provided through PRM experiments (MS) is an efficient method for the fast and accurate analysis of a complex mixture of annonaceous acetogenins, with the identification of sylvaticin and gigantetrocin-A type acetogenins for the first time. In addition, the crude leaf extract and acetogenin-rich fractions were assayed against , , and strains, which are usually related to oral infections.

Mart. Fractions Promote Cell Cycle Arrest and Inhibit Autophagic Flux in Human Cervical Cancer Cell Lines.

Plant-based compounds are an option to explore and perhaps overcome the limitations of current antitumor treatments. Mart. is a plant with a broad spectrum of biological activities, but its antitumor activity is still unclear.