Preference for a fixed combination of brinzolamide/timolol versus dorzolamide/timolol among patients with open-angle glaucoma or ocular hypertension.

Objective: To assess ocular discomfort upon instillation and patient preference for brinzolamide/timolol relative to dorzolamide/timolol, in patients with open-angle glaucoma or ocular hypertension.

Methods: This was a multicenter, prospective, patient-masked, randomized, crossover study. On day 0, patients received one drop of brinzolamide/timolol in one eye and one drop of dorzolamide/timolol in the contralateral eye.

Systems for staging the amount of optic nerve damage in glaucoma: a critical review and new material.

The evaluation of the appearance of the optic disk is central to the diagnosis and management of patients with glaucoma. Grouping patients into categories, monitoring change, and quantitating the rate of change all require some type of quantitative staging of the amount of damage. Though the scientific literature regarding the appearance of the optic disk in glaucoma is extensive, there is remarkably little about quantitative staging of the amount of damage.